Sympathetic hyperactivity and aortic sympathetic nerve sprouting in patients with thoracic aortic dissection.
Ann Vasc Surg
; 28(5): 1243-8, 2014 Jul.
Article
en En
| MEDLINE
| ID: mdl-24440187
ABSTRACT
BACKGROUND:
To determine the yet unknown relation between thoracic aortic dissection (TAD) and sympathetic nervous system activity.METHODS:
Variables such as electrocardiography, blood pressure, respiratory activity, postganglionic muscle sympathetic nerve activity (MSNA), plasma norepinephrine, tyrosine hydroxylase-positive nerve fiber density, and growth-associated protein 43-positive nerve fiber density were detected and statistically analyzed.RESULTS:
TAD Patients showed a significant lower R-R interval variance and higher blood pressure, heart rate, respiratory rate, MSNA, plasma norepinephrine (reflecting elevated sympathetic nervous system [SNS] activity), higher tyrosine hydroxylase, growth-associated protein 43-positive nerve fiber density (reflecting sympathetic sprouting and innervation) than those of the control group.CONCLUSIONS:
In TAD patients, both overall and regional aortic SNS activities are elevated.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aorta Torácica
/
Sistema Nervioso Simpático
/
Aneurisma de la Aorta Torácica
/
Disección Aórtica
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Ann Vasc Surg
Asunto de la revista:
ANGIOLOGIA
Año:
2014
Tipo del documento:
Article
País de afiliación:
China