ATF3 activates Stat3 phosphorylation through inhibition of p53 expression in skin cancer cells.
Asian Pac J Cancer Prev
; 14(12): 7439-44, 2013.
Article
en En
| MEDLINE
| ID: mdl-24460316
ABSTRACT
AIM:
ATF3, a member of the ATF/CREB family of transcription factors, has been found to be selectively induced by calcineurin/NFAT inhibition and to enhance keratinocyte tumor formation, although the precise role of ATF3 in human skin cancer and possible mechanisms remain unknown.METHODS:
In this study, clinical analysis of 30 skin cancer patients and 30 normal donors revealed that ATF3 was accumulated in skin cancer tissues. Functional assays demonstrated that ATF3 significantly promoted skin cancer cell proliferation.RESULTS:
Mechanically, ATF3 activated Stat3 phosphorylation in skin cancer cell through regulation of p53 expression. Moreover, the promotion effect of ATF3 on skin cancer cell proliferation was dependent on the p53-Stat3 signaling cascade.CONCLUSION:
Together, the results indicate that ATF3 might promote skin cancer cell proliferation and enhance skin keratinocyte tumor development through inhibiting p53 expression and then activating Stat3 phosphorylation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piel
/
Neoplasias Cutáneas
/
Carcinoma de Células Escamosas
/
Proteína p53 Supresora de Tumor
/
Proliferación Celular
/
Factor de Transcripción STAT3
/
Factor de Transcripción Activador 3
Límite:
Humans
Idioma:
En
Revista:
Asian Pac J Cancer Prev
Asunto de la revista:
NEOPLASIAS
Año:
2013
Tipo del documento:
Article