Immunohistochemical expression of MMP-14 and MMP-2, and MMP-2 activity during human ovarian follicular development.
Reprod Biol Endocrinol
; 12: 12, 2014 Jan 31.
Article
en En
| MEDLINE
| ID: mdl-24485069
ABSTRACT
BACKGROUND:
The aim of this study was to investigate the presence of MMP-14 and MMP-2 during human ovarian follicular development using immunohistochemistry, and the activity of MMP-2 in follicular fluid using zymography.METHODS:
Ovarian tissue collected from the archives of the Department of Pathology was examined and medical records and histopathology were reviewed. Follicular fluids were collected at the IVF-department and analyzed using zymography.RESULTS:
MMP-14 and MMP-2 were increasingly found in the growing follicles and MMP-2 was highly expressed in the corpus luteum. Pro-MMP-2 was present in follicular fluid of IVF-patients.CONCLUSIONS:
The presence of MMP-14 and MMP-2 during human ovarian follicular development from the primordial follicle to the tertiary follicle and corpus luteum is confirmed, as was indicated by earlier animal studies following stimulation with gonadotrophins.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Regulación Enzimológica de la Expresión Génica
/
Metaloproteinasa 2 de la Matriz
/
Metaloproteinasa 14 de la Matriz
/
Folículo Ovárico
Tipo de estudio:
Observational_studies
Límite:
Adult
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Female
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Humans
/
Middle aged
Idioma:
En
Revista:
Reprod Biol Endocrinol
Asunto de la revista:
ENDOCRINOLOGIA
/
MEDICINA REPRODUTIVA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Países Bajos