Isavuconazole therapy protects immunosuppressed mice from mucormycosis.
Antimicrob Agents Chemother
; 58(4): 2450-3, 2014.
Article
en En
| MEDLINE
| ID: mdl-24492363
ABSTRACT
We studied the in vitro and in vivo efficacies of the investigational drug isavuconazole against mucormycosis due to Rhizopus delemar. Isavuconazole was effective, with MIC and minimal fungicidal concentration (MFC) values ranging between 0.125 and 1.00 µg/ml. A high dose of isavuconazole prolonged the survival time and lowered the tissue fungal burden of cyclophosphamide/cortisone acetate-treated mice infected with R. delemar and was as effective as a high-dose liposomal amphotericin B treatment. These results support the further development of this azole against mucormycosis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piridinas
/
Triazoles
/
Mucormicosis
/
Antifúngicos
/
Nitrilos
Límite:
Animals
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2014
Tipo del documento:
Article
País de afiliación:
Estados Unidos