Cell-based delivery of brain-derived neurotrophic factor in experimental allergic encephalomyelitis.
J Interferon Cytokine Res
; 34(8): 641-7, 2014 Aug.
Article
en En
| MEDLINE
| ID: mdl-24601738
ABSTRACT
Brain-derived neurotrophic factor (BDNF) is a pleiotropic cytokine with neuroprotective properties that has been identified as a potential therapeutic agent for diseases of the central nervous system (CNS). The use of BDNF has been limited by a short serum half-life and poor penetration of the blood-brain barrier. To address this limitation we have explored cell-based approaches to delivery. We have used experimental allergic encephalomyelitis (EAE), an inflammatory disease of the CNS, as a model system. We engineered hematopoietic stem cells to produce BDNF to determine the feasibility and effectiveness of cell-based delivery of BDNF into the CNS in EAE. We review those studies here.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Células Madre Hematopoyéticas
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Barrera Hematoencefálica
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Sistema Nervioso Central
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Fármacos Neuroprotectores
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Factor Neurotrófico Derivado del Encéfalo
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Encefalomielitis Autoinmune Experimental
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Interferon Cytokine Res
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2014
Tipo del documento:
Article