Ectopic apocrine glands as a predisposing factor for postinflammatory medial meatal fibrosis: a clinicopathologic study.
Otol Neurotol
; 36(1): 191-7, 2015 Jan.
Article
en En
| MEDLINE
| ID: mdl-24643031
ABSTRACT
OBJECTIVE:
To illuminate pathophysiologic processes in postinflammatory medial meatal fibrosis (PMMF), a rare otologic disease of unknown etiology, which is defined by a progressive, obliterating fibrosis that affects the osseous part of the external auditory canal (EAC) exclusively. STUDYDESIGN:
Retrospective clinical and histopathologic study.SETTING:
Tertiary referral center. PATIENTS Eleven patients (4 female and 7 male subjects) who underwent surgery of the bony EAC due to PMMF (13 ears operated).METHODS:
Histologic and immunohistochemical assessment of tissue specimens obtained during surgical excision. MAIN OUTCOMEMEASURE:
Detection of ectopic apocrine glands and concomitant inflammatory infiltrate within tissue harvested from the osseous EAC.RESULTS:
Additionally to expected histologic findings, such as excessive fibrosis and a chronic inflammatory infiltrate, ectopic spread of apocrine glands was consistently detected in all of our patients.CONCLUSION:
Based on our findings, we suggest that an ectopic occurrence of adnexal structures within the bony EAC may predispose susceptible individuals to the development of PMMF. To avoid postoperative recurrence due to iatrogenic spread of cutaneous adnexal structures during surgery, the split-thickness skin graft should not exceed a thickness of 0.4 mm.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Glándulas Apocrinas
/
Coristoma
/
Conducto Auditivo Externo
/
Enfermedades del Oído
Tipo de estudio:
Observational_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Otol Neurotol
Asunto de la revista:
NEUROLOGIA
/
OTORRINOLARINGOLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Austria