Allele-specific silencing of mutant Ataxin-7 in SCA7 patient-derived fibroblasts.

Scholefield, Janine; Watson, Lauren; Smith, Danielle; Greenberg, Jacquie; Wood, Matthew J A

Scholefield, Janine; Watson, Lauren; Smith, Danielle; Greenberg, Jacquie; Wood, Matthew J A.

Afiliación

Scholefield J; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Watson L; 1] Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK [2] Division of Human Genetics, Department of Clinical Laboratory Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Smith D; Division of Human Genetics, Department of Clinical Laboratory Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Greenberg J; Division of Human Genetics, Department of Clinical Laboratory Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Wood MJ; 1] Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK [2] Division of Human Genetics, Department of Clinical Laboratory Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

Eur J Hum Genet ; 22(12): 1369-75, 2014 Dec.

Article en En | MEDLINE | ID: mdl-24667781

Asunto(s)

Alelos; Fibroblastos/metabolismo; Silenciador del Gen; Proteínas del Tejido Nervioso/genética; Ataxina-7; Línea Celular; Técnicas de Genotipaje; Proteínas del Choque Térmico HSP40/genética; Proteínas del Choque Térmico HSP40/metabolismo; Humanos; Proteínas del Tejido Nervioso/metabolismo; Enfermedades Neurodegenerativas/genética; Enfermedades Neurodegenerativas/terapia; Fenotipo; Polimorfismo de Nucleótido Simple; Interferencia de ARN; ARN Interferente Pequeño/genética; ARN Interferente Pequeño/metabolismo; Ubiquitina Tiolesterasa/genética; Ubiquitina Tiolesterasa/metabolismo

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Silenciador del Gen / Alelos / Fibroblastos / Proteínas del Tejido Nervioso Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Eur J Hum Genet Asunto de la revista: GENETICA MEDICA Año: 2014 Tipo del documento: Article País de afiliación: Reino Unido

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