Nodal promotes the self-renewal of human colon cancer stem cells via an autocrine manner through Smad2/3 signaling pathway.

Gong, Yuehua; Guo, Ying; Hai, Yanan; Yang, Hao; Liu, Yang; Yang, Shi; Zhang, Zhenzhen; Ma, Meng; Liu, Linhong; Li, Zheng; He, Zuping

Gong, Yuehua; Guo, Ying; Hai, Yanan; Yang, Hao; Liu, Yang; Yang, Shi; Zhang, Zhenzhen; Ma, Meng; Liu, Linhong; Li, Zheng; He, Zuping.

Afiliación

Gong Y; State Key Laboratory of Oncogenes and Related Genes, Stem Cell Research Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 1630 Dongfang Road, Shanghai 200127, China.
Guo Y; State Key Laboratory of Oncogenes and Related Genes, Stem Cell Research Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 1630 Dongfang Road, Shanghai 200127, China.
Hai Y; State Key Laboratory of Oncogenes and Related Genes, Stem Cell Research Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 1630 Dongfang Road, Shanghai 200127, China.
Yang H; State Key Laboratory of Oncogenes and Related Genes, Stem Cell Research Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 1630 Dongfang Road, Shanghai 200127, China.
Liu Y; State Key Laboratory of Oncogenes and Related Genes, Stem Cell Research Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 1630 Dongfang Road, Shanghai 200127, China.
Yang S; Department of Urology, Shanghai Human Sperm Bank, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 145 Shandong, Shanghai 200001, China.
Zhang Z; State Key Laboratory of Oncogenes and Related Genes, Stem Cell Research Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 1630 Dongfang Road, Shanghai 200127, China.
Ma M; Department of Urology, Shanghai Human Sperm Bank, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 145 Shandong, Shanghai 200001, China.
Liu L; State Key Laboratory of Oncogenes and Related Genes, Stem Cell Research Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 1630 Dongfang Road, Shanghai 200127, China.
Li Z; Department of Urology, Shanghai Human Sperm Bank, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 145 Shandong, Shanghai 200001, China.
He Z; State Key Laboratory of Oncogenes and Related Genes, Stem Cell Research Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 1630 Dongfang Road, Shanghai 200127, China ; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai 200001, China ; Shangha

Biomed Res Int ; 2014: 364134, 2014.

Article en En | MEDLINE | ID: mdl-24696849

Asunto(s)

Comunicación Autocrina; Neoplasias del Colon/patología; Células Madre Neoplásicas/metabolismo; Células Madre Neoplásicas/patología; Proteína Nodal/metabolismo; Proteína Smad2/metabolismo; Proteína smad3/metabolismo; Antígeno CD24/metabolismo; Línea Celular Tumoral; Proliferación Celular; Colon/metabolismo; Colon/patología; Neoplasias del Colon/genética; Regulación Neoplásica de la Expresión Génica; Humanos; Receptores de Hialuranos/metabolismo; Ligandos; Proteína Nodal/genética; ARN Mensajero/genética; ARN Mensajero/metabolismo; Transducción de Señal/genética; Esferoides Celulares/metabolismo; Esferoides Celulares/patología

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Neoplasias del Colon / Comunicación Autocrina / Proteína Smad2 / Proteína smad3 / Proteína Nodal Límite: Humans Idioma: En Revista: Biomed Res Int Año: 2014 Tipo del documento: Article País de afiliación: China

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