Naturally Occurring Cytotoxic [3'â8â³]-Biflavonoids from Podocarpus nakaii.
J Tradit Complement Med
; 2(3): 220-6, 2012 Jul.
Article
en En
| MEDLINE
| ID: mdl-24716136
ABSTRACT
Bioassay-guided fractionation of the EtOH extract of the dried twigs of Podocarpus nakaii Hayata (Podocarpaceae), endemic plant in Taiwan has resulted in isolation of four [3'â8â³]-biflavonoid derivatives, amenotoflavone (AF), podocarpusflavone-A (PF), II-4â³,I-7-dimethoxyamentoflavone (DAF), and heveaflavone (HF). Their structures were determined by physical and extensive spectroscopic analyses such as (1)H, (13)C, (1)H-(1)H COSY, HMQC, and HMBC, as well as comparison with literature values. Compounds PF and DAF showed significant inhibitions against DLD, KB, MCF-7, HEp-2 tumor cell lines (ED50 ca. 4.56-16.24 µg/mL) and induced cell apoptosis in MCF-7 via mainly sub-G1/S phase arrest. Furthermore, these compounds exhibited moderate Topoisomerase I inhibitory activity.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
J Tradit Complement Med
Año:
2012
Tipo del documento:
Article
País de afiliación:
Taiwán