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Naturally Occurring Cytotoxic [3'→8″]-Biflavonoids from Podocarpus nakaii.
Yeh, Pen-Ho; Shieh, Yun-Dar; Hsu, Li-Chun; Kuo, Li-Ming Yang; Lin, Jhih-Hu; Liaw, Chia-Ching; Kuo, Yao-Haur.
Afiliación
  • Yeh PH; Institute of Pharmacology, National Yang-Ming University, Taipei 112, Taiwan.
  • Shieh YD; Institute of Pharmacology, National Yang-Ming University, Taipei 112, Taiwan ; National Research Institute of Chinese Medicine, Taipei 112, Taiwan.
  • Hsu LC; National Research Institute of Chinese Medicine, Taipei 112, Taiwan ; Department of Biochemical Science and Technology, National Taiwan University, Taipei 106, Taiwan.
  • Kuo LM; National Research Institute of Chinese Medicine, Taipei 112, Taiwan ; School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan.
  • Lin JH; National Research Institute of Chinese Medicine, Taipei 112, Taiwan.
  • Liaw CC; National Research Institute of Chinese Medicine, Taipei 112, Taiwan.
  • Kuo YH; National Research Institute of Chinese Medicine, Taipei 112, Taiwan ; Graduate Institute of Integrated Medicine, China Medical University, Taichung 404, Taiwan.
J Tradit Complement Med ; 2(3): 220-6, 2012 Jul.
Article en En | MEDLINE | ID: mdl-24716136
ABSTRACT
Bioassay-guided fractionation of the EtOH extract of the dried twigs of Podocarpus nakaii Hayata (Podocarpaceae), endemic plant in Taiwan has resulted in isolation of four [3'→8″]-biflavonoid derivatives, amenotoflavone (AF), podocarpusflavone-A (PF), II-4″,I-7-dimethoxyamentoflavone (DAF), and heveaflavone (HF). Their structures were determined by physical and extensive spectroscopic analyses such as (1)H, (13)C, (1)H-(1)H COSY, HMQC, and HMBC, as well as comparison with literature values. Compounds PF and DAF showed significant inhibitions against DLD, KB, MCF-7, HEp-2 tumor cell lines (ED50 ca. 4.56-16.24 µg/mL) and induced cell apoptosis in MCF-7 via mainly sub-G1/S phase arrest. Furthermore, these compounds exhibited moderate Topoisomerase I inhibitory activity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Tradit Complement Med Año: 2012 Tipo del documento: Article País de afiliación: Taiwán
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Tradit Complement Med Año: 2012 Tipo del documento: Article País de afiliación: Taiwán