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The target gene carrying validity to HePG2 cells with the brush-like glutathione modified chitosan compound.
Li, Congxin; Zhou, Dezhong; Hu, Yuling; Zhou, Hao; Chen, Jiatong; Zhang, Zhengpu; Guo, Tianying.
Afiliación
  • Li C; Key Laboratory of Functional Polymer Materials (Nankai University), Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Weijin Road, No. 94, Tianjin 300071, China.
  • Zhou D; Key Laboratory of Functional Polymer Materials (Nankai University), Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Weijin Road, No. 94, Tianjin 300071, China.
  • Hu Y; Key Laboratory of Functional Polymer Materials (Nankai University), Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Weijin Road, No. 94, Tianjin 300071, China.
  • Zhou H; Department of Biochemistry and Molecular Biology, College of Life Science, Nankai University, Weijin Road, No. 94, Tianjin 300071, China.
  • Chen J; Department of Biochemistry and Molecular Biology, College of Life Science, Nankai University, Weijin Road, No. 94, Tianjin 300071, China.
  • Zhang Z; Key Laboratory of Functional Polymer Materials (Nankai University), Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Weijin Road, No. 94, Tianjin 300071, China.
  • Guo T; Key Laboratory of Functional Polymer Materials (Nankai University), Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Weijin Road, No. 94, Tianjin 300071, China.
Carbohydr Polym ; 89(1): 46-53, 2012 Jun 05.
Article en En | MEDLINE | ID: mdl-24750602
ABSTRACT
The grafting modified chitosan with L-glutathione (GSH) end capped PEG brush-like poly [poly(ethylene glycol) methacrylate] (PMPEG), CS-PMPEG-GSH, as the pDNA condensed vector material could result in a much higher transfection efficiency and lower cytotoxity for NIH3T3 cells. In this work, we have further examined the morphology stabilities of CS-PMPEG-GSH/pDNA vectors at different medium pH values and in the presence of serum protein in detail. And then the targeted characters for HepG2 cells have been probed by tracing the cell uptake behavior and transfection efficiency.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polietilenglicoles / ADN / Técnicas de Transferencia de Gen / Quitosano / Glutatión / Metacrilatos Límite: Animals / Humans Idioma: En Revista: Carbohydr Polym Año: 2012 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polietilenglicoles / ADN / Técnicas de Transferencia de Gen / Quitosano / Glutatión / Metacrilatos Límite: Animals / Humans Idioma: En Revista: Carbohydr Polym Año: 2012 Tipo del documento: Article País de afiliación: China