Dynorphin release by the lateral olivocochlear efferents may inhibit auditory nerve activity: a cochlear drug delivery study.
Neurosci Lett
; 571: 17-22, 2014 Jun 13.
Article
en En
| MEDLINE
| ID: mdl-24780562
ABSTRACT
Dynorphin (dyn) is suggested to excite the auditory nerve (AN) when released by the lateral olivocochlear (LOC) efferents. However, previous studies evaluated either intravenously delivered dyn-like agents, raising the potential for systemic (central) effects, or agent concentrations unlikely to be achieved via endogenous cochlear release. This study tested the hypothesis that biologically relevant increases in dyn levels in the cochlea achieved via diffusion of the drug of (-)pentazocine across the round window membrane enhances AN firing. In general, amplitude of the cochlear whole-nerve action potential (CAP) was depressed following drug application. These results suggest that dyn released by the LOC neurons would likely act as an inhibitory transmitter substance in the LOC system; neurotransmission is one of the LOC system's vast unknowns.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pentazocina
/
Dinorfinas
/
Cóclea
/
Nervio Coclear
/
Receptores Opioides kappa
/
Complejo Olivar Superior
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
2014
Tipo del documento:
Article