Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.

Fang, Evandro Fei; Scheibye-Knudsen, Morten; Brace, Lear E; Kassahun, Henok; SenGupta, Tanima; Nilsen, Hilde; Mitchell, James R; Croteau, Deborah L; Bohr, Vilhelm A

Fang, Evandro Fei; Scheibye-Knudsen, Morten; Brace, Lear E; Kassahun, Henok; SenGupta, Tanima; Nilsen, Hilde; Mitchell, James R; Croteau, Deborah L; Bohr, Vilhelm A.

Afiliación

Fang EF; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Scheibye-Knudsen M; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Brace LE; Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
Kassahun H; The Biotechnology Center, University of Oslo, Oslo 0317, Norway.
SenGupta T; The Biotechnology Center, University of Oslo, Oslo 0317, Norway.
Nilsen H; The Biotechnology Center, University of Oslo, Oslo 0317, Norway.
Mitchell JR; Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
Croteau DL; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Bohr VA; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

Cell ; 157(4): 882-896, 2014 May 08.

Article en En | MEDLINE | ID: mdl-24813611

Asunto(s)

Mitofagia; Poli(ADP-Ribosa) Polimerasas/metabolismo; Sirtuina 1/metabolismo; Proteína de la Xerodermia Pigmentosa del Grupo A/metabolismo; Xerodermia Pigmentosa/fisiopatología; Envejecimiento; Animales; Apoptosis; Autofagia; Caenorhabditis elegans; Línea Celular; Humanos; Canales Iónicos/metabolismo; Ratones; Proteínas Mitocondriales/metabolismo; Proteínas Quinasas/metabolismo; Ratas; Proteína Desacopladora 2; Xerodermia Pigmentosa/metabolismo

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 / 6_ODS3_enfermedades_notrasmisibles Problema de salud: 1_doencas_nao_transmissiveis / 6_congenital_chromosomal_anomalies / 6_endocrine_disorders / 6_skin_diseases Asunto principal: Xerodermia Pigmentosa / Poli(ADP-Ribosa) Polimerasas / Proteína de la Xerodermia Pigmentosa del Grupo A / Sirtuina 1 / Mitofagia Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Cell Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos

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