First report on the antibody verification of HLA-ABC epitopes recorded in the website-based HLA Epitope Registry.
Tissue Antigens
; 83(6): 391-400, 2014 Jun.
Article
en En
| MEDLINE
| ID: mdl-24828056
ABSTRACT
The International Registry of Antibody-Defined HLA Epitopes ( http//www.epregistry.com.br) has been recently established as a tool to understand humoral responses to human leukocyte antigen (HLA) mismatches. These epitopes are defined structurally by three-dimensional molecular modeling and amino acid sequence differences between HLA antigens. So-called eplets represent essential components of HLA epitopes and they are defined by polymorphic residues. A major goal is to identify HLA epitopes that have been verified experimentally with informative antibodies. Our analysis has also included data in many publications. As of 1 November 2013, 95 HLA-ABC antibody-verified epitopes have been recorded, 62 correspond to eplets and 33 are defined by eplets paired with other residue configurations. The Registry is still a work-in-progress and will become a useful resource for HLA professionals interested in histocompatibility testing at the epitope level and investigating antibody responses to HLA mismatches in transplant patients.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Prueba de Histocompatibilidad
/
Genes MHC Clase I
/
Sistema de Registros
/
Bases de Datos de Proteínas
/
Antígenos HLA
/
Isoanticuerpos
/
Anticuerpos Monoclonales
/
Epítopos
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Tissue Antigens
Año:
2014
Tipo del documento:
Article
País de afiliación:
Estados Unidos