Amitriptyline, minocycline and maropitant reduce the sevoflurane minimum alveolar concentration and potentiate remifentanil but do not prevent acute opioid tolerance and hyperalgesia in the rat: a randomised laboratory study.
Eur J Anaesthesiol
; 32(4): 248-54, 2015 Apr.
Article
en En
| MEDLINE
| ID: mdl-24849503
ABSTRACT
BACKGROUND:
The antidepressant amitriptyline, the inhibitor of microglia activation minocycline, and the neurokinin-1 antagonist maropitant have all been used to prevent or treat hyperalgesia and opioid tolerance.OBJECTIVES:
To determine the effect of amitriptyline, minocycline, maropitant, independently or with remifentanil, on the sevoflurane minimum alveolar concentration in rats and whether these drugs may block opioid-induced hyperalgesia and acute opioid tolerance under inhalational anaesthesia.DESIGN:
A randomised, laboratory study.SETTING:
Experimental Unit, La Paz University Hospital, Madrid, Spain. ANIMALS One hundred and fourteen adult male Wistar rats.INTERVENTIONS:
Intraperitoneal administration of amitriptyline (10 and 50 âmgâ kg-1), minocycline (30 and 100 âmgâ kg-1), maropitant (10 and 30âmgâ kg-1) or isotonic saline, combined with a constant rate intravenous infusion of remifentanil (240âµgâ kg-1 âh-1) or saline. MAIN OUTCOMEMEASURES:
Sevoflurane minimum alveolar concentration was determined before and after administration of the drugs; acute opioid tolerance was defined as a decreased ability of remifentanil to reduce the minimum alveolar concentration in the short term. In addition, mechanical nociceptive thresholds were determined before and after these treatments. Opioid-induced hyperalgesia was defined as an increase in mechanical nociceptive thresholds after opioid administration.RESULTS:
Amitriptyline, minocycline and maropitant reduced minimum alveolar concentration up to 24 (8)%, 23 (6)% and 15 (5)%, respectively (Pâ<0.001). Remifentanil alone reduced minimum alveolar concentration by 36 (6)% (Pâ<0.001), and in combination with amitriptyline, minocycline and maropitant, the reduction was 76 (9)%, 75 (16)% and 59 (5)%, respectively (Pâ<0.001). An acute tolerance effect (Pâ<â0.01) and a decrease in the mechanical nociceptive thresholds were observed with remifentanil in all groups.CONCLUSION:
Amitriptyline, minocycline and maropitant reduced the minimum alveolar concentration and potentiated the remifentanil minimum alveolar concentration reduction but failed to block opioid-induced hyperalgesia and acute opioid tolerance.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
Problema de salud:
1_doencas_nao_transmissiveis
Asunto principal:
Piperidinas
/
Alveolos Pulmonares
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Quinuclidinas
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Anestésicos por Inhalación
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Tolerancia a Medicamentos
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Amitriptilina
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Hiperalgesia
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Analgésicos Opioides
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Éteres Metílicos
/
Minociclina
Límite:
Animals
Idioma:
En
Revista:
Eur J Anaesthesiol
Asunto de la revista:
ANESTESIOLOGIA
Año:
2015
Tipo del documento:
Article