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Cystic echinococcoses in Mongolia: molecular identification, serology and risk factors.
Ito, Akira; Dorjsuren, Temuulen; Davaasuren, Anu; Yanagida, Tetsuya; Sako, Yasuhito; Nakaya, Kazuhiro; Nakao, Minoru; Bat-Ochir, Oyun-Erdene; Ayushkhuu, Tsendjav; Bazarragchaa, Narantuya; Gonchigsengee, Nyamkhuu; Li, Tiaoying; Agvaandaram, Gurbadam; Davaajav, Abmed; Boldbaatar, Chinchuluun; Chuluunbaatar, Gantigmaa.
Afiliación
  • Ito A; Department of Parasitology, Asahikawa Medical University, Asahikawa, Japan.
  • Dorjsuren T; Department of Parasitology, Asahikawa Medical University, Asahikawa, Japan; Department of Medical Biology and Histology, School of Biomedicine, Health Sciences University of Mongolia, Ulaanbaatar, Mongolia.
  • Davaasuren A; Department of Parasitology, Asahikawa Medical University, Asahikawa, Japan; National Center for Communicable Diseases, Ulaanbaatar, Mongolia.
  • Yanagida T; Department of Parasitology, Asahikawa Medical University, Asahikawa, Japan.
  • Sako Y; Department of Parasitology, Asahikawa Medical University, Asahikawa, Japan.
  • Nakaya K; Department of Parasitology, Asahikawa Medical University, Asahikawa, Japan.
  • Nakao M; Department of Parasitology, Asahikawa Medical University, Asahikawa, Japan.
  • Bat-Ochir OE; National Center of Pathology, Ulaanbaatar, Mongolia.
  • Ayushkhuu T; National Center for Maternal and Child Health, Ulaanbaatar, Mongolia.
  • Bazarragchaa N; Department of Surgery, State Central First Hospital, Ulaanbaatar, Mongolia.
  • Gonchigsengee N; Department of Surgery, State Central First Hospital, Ulaanbaatar, Mongolia.
  • Li T; Department of Parasitology, Asahikawa Medical University, Asahikawa, Japan; Institute of Parasitic Diseases, Sichuan Centers for Disease Control and Prevention, Chengdu, China.
  • Agvaandaram G; Department of Medical Biology and Histology, School of Biomedicine, Health Sciences University of Mongolia, Ulaanbaatar, Mongolia.
  • Davaajav A; Department of Parasitology, Asahikawa Medical University, Asahikawa, Japan; National Center for Communicable Diseases, Ulaanbaatar, Mongolia.
  • Boldbaatar C; Department of Parasitology, Asahikawa Medical University, Asahikawa, Japan; Institute of Veterinary Medicine, Ulaanbaatar, Mongolia.
  • Chuluunbaatar G; Department of Parasitology, Asahikawa Medical University, Asahikawa, Japan; Mongolian Academy of Science, Ulaanbaatar, Mongolia.
PLoS Negl Trop Dis ; 8(6): e2937, 2014 Jun.
Article en En | MEDLINE | ID: mdl-24945801
ABSTRACT

BACKGROUND:

Cystic echinococcosis (CE) is a globally distributed cestode zoonosis that causes hepatic cysts. Although Echinococcus granulosus sensu stricto (s.s.) is the major causative agent of CE worldwide, recent molecular epidemiological studies have revealed that E. canadensis is common in countries where camels are present. One such country is Mongolia. METHODOLOGY/PRINCIPAL

FINDINGS:

Forty-three human hepatic CE cases that were confirmed histopathologically at the National Center of Pathology (NCP) in Ulaanbaatar (UB) were identified by analysis of mitochondrial cox 1 gene as being caused by either E. canadensis (n=31, 72.1%) or E. granulosus s.s. (n=12, 27.9%). The majority of the E. canadensis cases were strain G6/7 (29/31, 93.5%). Twenty three haplotypes were identified. Sixteen of 39 CE cases with data on age, sex and province of residence were citizens of UB (41.0%), with 13 of the 16 cases from UB caused by E. canadensis (G6/7) (81.3%). Among these 13 cases, nine were children (69.2%). All pediatric cases (n  =  18) were due to E. canadensis with 17 of the 18 cases (94.4%) due to strain G6/7. Serum samples were available for 31 of the 43 CE cases, with 22 (71.0%) samples positive by ELISA to recombinant Antigen B8/1 (rAgB). Nine of 10 CE cases caused by E. granulosus s.s. (90.0%) and 13 of 20 CE cases by E. canadensis (G6/7) (65.0%) were seropositive. The one CE case caused by E. canadensis (G10) was seronegative. CE cases caused by E. granulosus s.s. showed higher absorbance values (median value 1.131) than those caused by E. canadensis (G6/7) (median value 0.106) (p  =  0.0137). CONCLUSION/

SIGNIFICANCE:

The main species/strains in the study population were E. canadenis and E. granulossus s.s. with E. canadensis the predominant species identified in children. The reason why E. canadensis appears to be so common in children is unknown.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_helminthiasis / 3_neglected_diseases / 3_zoonosis Asunto principal: Equinococosis Hepática / Echinococcus Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Animals / Child / Child, preschool / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: PLoS Negl Trop Dis Asunto de la revista: MEDICINA TROPICAL Año: 2014 Tipo del documento: Article País de afiliación: Japón

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_helminthiasis / 3_neglected_diseases / 3_zoonosis Asunto principal: Equinococosis Hepática / Echinococcus Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Animals / Child / Child, preschool / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: PLoS Negl Trop Dis Asunto de la revista: MEDICINA TROPICAL Año: 2014 Tipo del documento: Article País de afiliación: Japón
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