The antibiotic and membrane-damaging activities of cellobiose lipids and sophorose lipids.
J Oleo Sci
; 63(7): 701-7, 2014.
Article
en En
| MEDLINE
| ID: mdl-24976613
ABSTRACT
Antibiotic activity was compared for Cryptococcus humicola cellobiose lipids, the mixture of 2,3,4-Ð-triacetyl-ß-D-glucopyranosyl-(1â4)-(6-Ð-acetyl-ß-D-glucopyranosyl-(1â16)-2,16-dihydroxyhexodecanoic acid and 2,3,4-Ð-triacetyl-ß-D-glucopyranosyl-(1â4)-(6-Ð-acetyl-ß-D-glucopyranosyl-(1â16)-2,17,18-trihydroxyoctotodecanoic acid, and the commercial sophorose lipid mixture of a mono-acetylated acidic sophorose lipid and a di-acetylated acidic sophorose lipid, both containing the C181 fatty acid residue. The MIC values of cellobiose lipids were 0.005 and 0.04 mg/mL for Filobasidiella neoformans and Candida tropicalis, respectively. The MIC values of sophorose lipids were 1 and 15 mg/mL for F. neoformans and C. tropicalis, respectively. MIC values for some bacteria were in the range of 10-30 mg/mL for both glycolipid preparations. Both sophorose lipids and cellobiose lipids displayed a membrane-damaging activity against F. neoformans. The treatment with these glycolipids reduces the content of ATP in the cells of test cultures and results in their staining with ethidium bromide.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Membrana Celular
/
Celobiosa
/
Cryptococcus neoformans
/
Candida tropicalis
/
Glucanos
/
Lípidos
/
Antibacterianos
/
Antifúngicos
Idioma:
En
Revista:
J Oleo Sci
Asunto de la revista:
BIOQUIMICA
Año:
2014
Tipo del documento:
Article