High-fat diet consumption disrupts memory and primes elevations in hippocampal IL-1ß, an effect that can be prevented with dietary reversal or IL-1 receptor antagonism.

Sobesky, Julia L; Barrientos, Ruth M; De May, Henning S; Thompson, Brittany M; Weber, Michael D; Watkins, Linda R; Maier, Steven F

Sobesky, Julia L; Barrientos, Ruth M; De May, Henning S; Thompson, Brittany M; Weber, Michael D; Watkins, Linda R; Maier, Steven F.

Afiliación

Sobesky JL; Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USA. Electronic address: julia.sobesky@colorado.edu.
Barrientos RM; Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USA.
De May HS; Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USA.
Thompson BM; Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USA.
Weber MD; Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USA.
Watkins LR; Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USA.
Maier SF; Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USA.

Brain Behav Immun ; 42: 22-32, 2014 Nov.

Article en En | MEDLINE | ID: mdl-24998196

Asunto(s)

Condicionamiento Psicológico/fisiología; Dieta Alta en Grasa; Hipocampo/metabolismo; Interleucina-1beta/metabolismo; Trastornos de la Memoria/etiología; Memoria/fisiología; Receptores de Interleucina-1/antagonistas & inhibidores; Animales; Condicionamiento Psicológico/efectos de los fármacos; Miedo; Hipocampo/efectos de los fármacos; Masculino; Memoria/efectos de los fármacos; Trastornos de la Memoria/metabolismo; Ratas; Ratas Wistar; Receptores de Interleucina-1/metabolismo

Palabras clave

Dietary reversal; Fear conditioning; High-fat diet; Hippocampus; Interleukin-1ß; Memory; hIL-1RA

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Interleucina-1 / Condicionamiento Psicológico / Interleucina-1beta / Dieta Alta en Grasa / Hipocampo / Memoria / Trastornos de la Memoria Límite: Animals Idioma: En Revista: Brain Behav Immun Asunto de la revista: ALERGIA E IMUNOLOGIA / CEREBRO / PSICOFISIOLOGIA Año: 2014 Tipo del documento: Article

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