Abnormal thyroid stimulating hormone, prolactin, and growth hormone responses to thyrotropin releasing hormone in abstinent alcoholic men with cerebral atrophy.
Psychiatry Res
; 28(1): 89-96, 1989 Apr.
Article
en En
| MEDLINE
| ID: mdl-2500677
ABSTRACT
The thyroid stimulating hormone (TSH), prolactin (PRL), and growth hormone (GH) responses to thyrotropin releasing hormone (TRH), the Wechsler Adult Intelligence Scale (WAIS) for cognitive impairment, and computed tomographic scans were evaluated in 15 nondepressed alcoholic men after 4 weeks of abstinence and in 10 normal controls. Both cognitive impairment and cerebral atrophy were found in 13 of the alcoholics. Eight alcoholics (seven with cerebral atrophy) had blunted TSH and PRL responses to TRH and a TRH-induced paradoxical increase of GH. This study demonstrates that besides affecting the TSH response to TRH, alcoholism often induces alterations of the PRL and GH secretory patterns in response to TRH. The severe brain damage caused by long-term alcoholism might be involved in the pathogenesis of these neuroendocrine alterations.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
2_ODS3
/
8_ODS3_consumo_sustancias_psicoactivas
Problema de salud:
2_sustancias_psicoativas
/
8_alcohol
Asunto principal:
Prolactina
/
Templanza
/
Encéfalo
/
Hormona del Crecimiento
/
Tirotropina
/
Hormona Liberadora de Tirotropina
/
Alcoholismo
Límite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Psychiatry Res
Año:
1989
Tipo del documento:
Article
País de afiliación:
Italia