Toga-like virus as a cause of fulminant hepatitis attributed to sporadic non-A, non-B.
J Med Virol
; 28(3): 150-5, 1989 Jul.
Article
en En
| MEDLINE
| ID: mdl-2502604
ABSTRACT
Virus-like particles (60-70 nm) with spiked surfaces budding into cell vacuoles and rod-shaped inclusions were detected in nuclei of hepatocytes from a British patient transplanted for sporadic non-A, non-B fulminant hepatitis (NANB-FHF), probably contracted in Kenya. Identical particles were seen in two successive grafts (days 2 and 10) at regrafting for recurrent FHF. Ultrastructural features resembled those of the RNA-containing arbovirus, Rift Valley fever virus, but serological markers against a representative panel for arboviruses (Togaviruses) and transmission in mice proved negative. The particles shared features with the different arboviruses seen in the hepatectomy specimen of a second patient with NANB-FHF, and in both patients an insect vector was implicated in the clinical history. The particles were identical in size to those of a third patient with NANB-FHF, who had remained in the United Kingdom. These findings, together with the recent report of isolation of an RNA-containing virus resembling the Togaviridae, in parenteral NANB, suggest that several exotic virus-like agents resembling the arboviruses may be involved in the aetiology of NANB, including in the sporadic forms of FHF in the United Kingdom.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Togaviridae
/
Trasplante de Hígado
/
Hepatitis C
/
Hepatitis Viral Humana
Tipo de estudio:
Diagnostic_studies
Límite:
Adolescent
/
Female
/
Humans
Idioma:
En
Revista:
J Med Virol
Año:
1989
Tipo del documento:
Article
País de afiliación:
Reino Unido