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Interferon-γ-producing B cells induce the formation of gastric lymphoid follicles after Helicobacter suis infection.
Yang, L; Yamamoto, K; Nishiumi, S; Nakamura, M; Matsui, H; Takahashi, S; Dohi, T; Okada, T; Kakimoto, K; Hoshi, N; Yoshida, M; Azuma, T.
Afiliación
  • Yang L; Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Yamamoto K; Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Nishiumi S; Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Nakamura M; Graduate School of Pharmaceutical Science, Kitasato University, Minato-ku, Tokyo, Japan.
  • Matsui H; Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Minato-ku, Tokyo, Japan.
  • Takahashi S; Third Department of Internal Medicine, Kyorin University, Tokyo, Japan.
  • Dohi T; Department of Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, Ichikawa, Japan.
  • Okada T; Department of Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, Ichikawa, Japan.
  • Kakimoto K; Department of Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, Ichikawa, Japan.
  • Hoshi N; Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Yoshida M; 1] Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan [2] The Integrated Center for Mass Spectrometry, Graduate School of Medicine, Kobe University, Kobe, Japan [3] Division of Metabolomics Research, Kobe University Graduate School
  • Azuma T; Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Mucosal Immunol ; 8(2): 279-95, 2015 Mar.
Article en En | MEDLINE | ID: mdl-25073677
ABSTRACT
Helicobacter (H.) suis is capable of infecting various animals including humans, and H. suis infections can lead to gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Recently, we reported that interferon-γ (IFN-γ) was highly expressed in the stomachs of H. suis-infected mice, but the direct relationship between the upregulation of IFN-γ expression and the formation of gastric lymphoid follicles after H. suis infection remains unclear. Here, we demonstrated that the IFN-γ produced by B cells plays an important role in the formation of gastric lymphoid follicles after H. suis infection. In addition, IFN-γ-producing B cells evoked gastric lymphoid follicle formation independent of T-cell help, suggesting that they are crucial for the development of gastric MALT induced by Helicobacter infection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estómago / Linfocitos B / Infecciones por Helicobacter / Interferón gamma / Helicobacter heilmannii / Mucosa Gástrica Límite: Animals Idioma: En Revista: Mucosal Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estómago / Linfocitos B / Infecciones por Helicobacter / Interferón gamma / Helicobacter heilmannii / Mucosa Gástrica Límite: Animals Idioma: En Revista: Mucosal Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Japón