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Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists.
Buzard, Daniel J; Kim, Sun Hee; Lehmann, Juerg; Han, Sangdon; Calderon, Imelda; Wong, Amy; Kawasaki, Andrew; Narayanan, Sanju; Bhat, Rohit; Gharbaoui, Tawfik; Lopez, Luis; Yue, Dawei; Whelan, Kevin; Al-Shamma, Hussien; Unett, David J; Shu, Hsin-Hui; Tung, Shiu-Feng; Chang, Steve; Chuang, Ching-Fen; Morgan, Michael; Sadeque, Abu; Chu, Zhi-Liang; Leonard, James N; Jones, Robert M.
Afiliación
  • Buzard DJ; Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92121, United States. Electronic address: dbuzard@arenapharm.com.
  • Kim SH; Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92121, United States.
  • Lehmann J; Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92121, United States.
  • Han S; Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92121, United States.
  • Calderon I; Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92121, United States.
  • Wong A; Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92121, United States.
  • Kawasaki A; Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92121, United States.
  • Narayanan S; Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92121, United States.
  • Bhat R; Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92121, United States.
  • Gharbaoui T; Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92121, United States.
  • Lopez L; Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92121, United States.
  • Yue D; Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92121, United States.
  • Whelan K; Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92121, United States.
  • Al-Shamma H; Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92121, United States.
  • Unett DJ; Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92121, United States.
  • Shu HH; Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92121, United States.
  • Tung SF; Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92121, United States.
  • Chang S; Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92121, United States.
  • Chuang CF; Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92121, United States.
  • Morgan M; Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92121, United States.
  • Sadeque A; Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92121, United States.
  • Chu ZL; Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92121, United States.
  • Leonard JN; Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92121, United States.
  • Jones RM; Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92121, United States.
Bioorg Med Chem Lett ; 24(17): 4332-5, 2014 Sep 01.
Article en En | MEDLINE | ID: mdl-25088191
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperidinas / Piridinas / Receptores Acoplados a Proteínas G / Descubrimiento de Drogas Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperidinas / Piridinas / Receptores Acoplados a Proteínas G / Descubrimiento de Drogas Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article