Gold-catalyzed asymmetric allylic substitution of free alcohols: an enantioselective approach to chiral chromans with quaternary stereocenters for the synthesis of vitamin E and analogues.
Chemistry
; 20(43): 13913-7, 2014 Oct 20.
Article
en En
| MEDLINE
| ID: mdl-25201099
ABSTRACT
The enantioselective synthesis of α- and γ-tocopherol (the most biologically active members of vitaminâ
E family) and analogues has been accomplished employing a new enantioselective gold catalyzed intramolecular allylic alkylation reaction followed by an olefin cross-metathesis as key steps. The methodology proved to be applicable to different olefins highlighting its potential for the synthesis of diverse libraries.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vitamina E
/
Cromanos
/
Alcoholes
/
Oro
Idioma:
En
Revista:
Chemistry
Asunto de la revista:
QUIMICA
Año:
2014
Tipo del documento:
Article