Lodenafil treatment in the monocrotaline model of pulmonary hypertension in rats.
J Bras Pneumol
; 40(4): 421-4, 2014.
Article
en En, Pt
| MEDLINE
| ID: mdl-25210965
ABSTRACT
We assessed the effects of lodenafil on hemodynamics and inflammation in the rat model of monocrotaline-induced pulmonary hypertension (PH). Thirty male Sprague-Dawley rats were randomly divided into three groups control; monocrotaline (experimental model); and lodenafil (experimental model followed by lodenafil treatment, p.o., 5 mg/kg daily for 28 days) Mean pulmonary artery pressure (mPAP) was obtained by right heart catheterization. We investigated right ventricular hypertrophy (RVH) and IL-1 levels in lung fragments. The number of cases of RVH was significantly higher in the monocrotaline group than in the lodenafil and control groups, as were mPAP and IL-1 levels. We conclude that lodenafil can prevent monocrotaline-induced PH, RVH, and inflammation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piperazinas
/
Pirimidinas
/
Carbonatos
/
Hipertensión Pulmonar
Límite:
Animals
Idioma:
En
/
Pt
Revista:
J Bras Pneumol
Año:
2014
Tipo del documento:
Article
País de afiliación:
Brasil