Correlating FAAH and anandamide cellular uptake inhibition using N-alkylcarbamate inhibitors: from ultrapotent to hyperpotent.

Nicolussi, Simon; Chicca, Andrea; Rau, Mark; Rihs, Sabine; Soeberdt, Michael; Abels, Christoph; Gertsch, Jürg

Nicolussi, Simon; Chicca, Andrea; Rau, Mark; Rihs, Sabine; Soeberdt, Michael; Abels, Christoph; Gertsch, Jürg.

Afiliación

Nicolussi S; Institute of Biochemistry and Molecular Medicine, NCCR TransCure, University of Bern, Bühlstrasse 28, CH-3012 Bern, Switzerland.
Chicca A; Institute of Biochemistry and Molecular Medicine, NCCR TransCure, University of Bern, Bühlstrasse 28, CH-3012 Bern, Switzerland.
Rau M; Institute of Biochemistry and Molecular Medicine, NCCR TransCure, University of Bern, Bühlstrasse 28, CH-3012 Bern, Switzerland.
Rihs S; Institute of Biochemistry and Molecular Medicine, NCCR TransCure, University of Bern, Bühlstrasse 28, CH-3012 Bern, Switzerland.
Soeberdt M; Dr. August Wolff GmbH & Co. KG Arzneimittel, D-33611 Bielefeld, Germany.
Abels C; Dr. August Wolff GmbH & Co. KG Arzneimittel, D-33611 Bielefeld, Germany.
Gertsch J; Institute of Biochemistry and Molecular Medicine, NCCR TransCure, University of Bern, Bühlstrasse 28, CH-3012 Bern, Switzerland. Electronic address: gertsch@ibmm.unibe.ch.

Biochem Pharmacol ; 92(4): 669-89, 2014 Dec 15.

Article en En | MEDLINE | ID: mdl-25283614

Asunto(s)

Amidohidrolasas/farmacocinética; Ácidos Araquidónicos/farmacocinética; Carbamatos/farmacología; Endocannabinoides/farmacocinética; Alcamidas Poliinsaturadas/farmacocinética; Línea Celular Tumoral; Humanos; Espectroscopía de Resonancia Magnética; Espectrometría de Masa por Ionización de Electrospray; Relación Estructura-Actividad

Palabras clave

(+)-R-WIN 55,212-2 (PubChem CID: 5311501); Anandamide (PubChem CID: 5281969); Anandamide transport; Anandamide uptake inhibition; BMS309403 (PubChem CID: 16122583); Carbamate; Correlation; Diclofenac (PubChem CID: 3033); Dipyridamole (PubChem CID: 3108); FAAH inhibition; Guineensine (PubChem CID: 6442405); Indomethacin (PubChem CID: 3715); LY2183240 (PubChem CID: 11507802); MK-571 (PubChem CID: 5281888); URB597 (PubChem CID: 1383884); Verapamil (PubChem CID: 62969)

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbamatos / Ácidos Araquidónicos / Endocannabinoides / Alcamidas Poliinsaturadas / Amidohidrolasas Límite: Humans Idioma: En Revista: Biochem Pharmacol Año: 2014 Tipo del documento: Article País de afiliación: Suiza

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google