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Synthesis and lipid-lowering evaluation of 3-methyl-1H-purine-2,6-dione derivatives as potent and orally available anti-obesity agents.
He, Linhong; Pei, Heying; Ma, Liang; Pu, Yuzhi; Chen, Jinying; Liu, Zhuowei; Ran, Yan; Lei, Lei; Fu, Suhong; Tang, Minghai; Peng, Aihua; Long, Chaofeng; Chen, Lijuan.
Afiliación
  • He L; State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, PR China.
  • Pei H; State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, PR China.
  • Ma L; State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, PR China.
  • Pu Y; State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, PR China.
  • Chen J; State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, PR China.
  • Liu Z; Guangdong ZhongSheng Pharmaceutical Co. Ltd., Dongguan 440100, Guangdong, PR China.
  • Ran Y; State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, PR China.
  • Lei L; State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, PR China.
  • Fu S; State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, PR China.
  • Tang M; State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, PR China.
  • Peng A; State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, PR China.
  • Long C; Guangdong ZhongSheng Pharmaceutical Co. Ltd., Dongguan 440100, Guangdong, PR China.
  • Chen L; State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, PR China. Electronic address: chenlijuan125@163.com.
Eur J Med Chem ; 87: 595-610, 2014 Nov 24.
Article en En | MEDLINE | ID: mdl-25299682
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Purinas / Fármacos Antiobesidad / Hipolipemiantes Límite: Animals Idioma: En Revista: Eur J Med Chem Año: 2014 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Purinas / Fármacos Antiobesidad / Hipolipemiantes Límite: Animals Idioma: En Revista: Eur J Med Chem Año: 2014 Tipo del documento: Article