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A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling.
Leslie, Daniel C; Waterhouse, Anna; Berthet, Julia B; Valentin, Thomas M; Watters, Alexander L; Jain, Abhishek; Kim, Philseok; Hatton, Benjamin D; Nedder, Arthur; Donovan, Kathryn; Super, Elana H; Howell, Caitlin; Johnson, Christopher P; Vu, Thy L; Bolgen, Dana E; Rifai, Sami; Hansen, Anne R; Aizenberg, Michael; Super, Michael; Aizenberg, Joanna; Ingber, Donald E.
Afiliación
  • Leslie DC; 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA. [3] Harvard Medical School, Boston, Massachusetts, USA. [4] Vascular Biology Program, Boston Chi
  • Waterhouse A; 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA. [3] Division of Newborn Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
  • Berthet JB; 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA. [3] Division of Newborn Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
  • Valentin TM; 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA.
  • Watters AL; 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA.
  • Jain A; 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA. [3] Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts, USA.
  • Kim P; 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.
  • Hatton BD; 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.
  • Nedder A; Animal Research, Boston Children's Hospital, Boston, Massachusetts, USA.
  • Donovan K; Animal Research, Boston Children's Hospital, Boston, Massachusetts, USA.
  • Super EH; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.
  • Howell C; 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.
  • Johnson CP; 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.
  • Vu TL; 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.
  • Bolgen DE; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.
  • Rifai S; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.
  • Hansen AR; 1] Harvard Medical School, Boston, Massachusetts, USA. [2] Division of Newborn Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
  • Aizenberg M; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.
  • Super M; 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA. [3] Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts, USA.
  • Aizenberg J; 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA. [3] Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts,
  • Ingber DE; 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA. [3] Harvard Medical School, Boston, Massachusetts, USA. [4] Vascular Biology Program, Boston Chi
Nat Biotechnol ; 32(11): 1134-40, 2014 Nov.
Article en En | MEDLINE | ID: mdl-25306244
ABSTRACT
Thrombosis and biofouling of extracorporeal circuits and indwelling medical devices cause significant morbidity and mortality worldwide. We apply a bioinspired, omniphobic coating to tubing and catheters and show that it completely repels blood and suppresses biofilm formation. The coating is a covalently tethered, flexible molecular layer of perfluorocarbon, which holds a thin liquid film of medical-grade perfluorocarbon on the surface. This coating prevents fibrin attachment, reduces platelet adhesion and activation, suppresses biofilm formation and is stable under blood flow in vitro. Surface-coated medical-grade tubing and catheters, assembled into arteriovenous shunts and implanted in pigs, remain patent for at least 8 h without anticoagulation. This surface-coating technology could reduce the use of anticoagulants in patients and help to prevent thrombotic occlusion and biofouling of medical devices.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 6_ODS3_enfermedades_notrasmisibles Problema de salud: 6_cardiovascular_diseases Asunto principal: Trombosis / Materiales Biocompatibles Revestidos / Incrustaciones Biológicas Límite: Animals / Humans Idioma: En Revista: Nat Biotechnol Asunto de la revista: BIOTECNOLOGIA Año: 2014 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 6_ODS3_enfermedades_notrasmisibles Problema de salud: 6_cardiovascular_diseases Asunto principal: Trombosis / Materiales Biocompatibles Revestidos / Incrustaciones Biológicas Límite: Animals / Humans Idioma: En Revista: Nat Biotechnol Asunto de la revista: BIOTECNOLOGIA Año: 2014 Tipo del documento: Article