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LDL-apheresis contributes to survival extension and renal function maintenance of severe diabetic nephropathy patients: a retrospective analysis.
Sato, Eiichi; Amaha, Mayuko; Nomura, Mayumi; Matsumura, Daisuke; Ueda, Yoshihiko; Nakamura, Tsukasa.
Afiliación
  • Sato E; Shin-Matsudo Central General Hospital, Japan; Department of Pathology, Dokkyo Medical University, Koshigaya Hospital, Japan. Electronic address: satou@db4.so-net.ne.jp.
  • Amaha M; Shin-Matsudo Central General Hospital, Japan.
  • Nomura M; Shin-Matsudo Central General Hospital, Japan.
  • Matsumura D; Shin-Matsudo Central General Hospital, Japan.
  • Ueda Y; Department of Pathology, Dokkyo Medical University, Koshigaya Hospital, Japan.
  • Nakamura T; Shin-Matsudo Central General Hospital, Japan.
Diabetes Res Clin Pract ; 106(2): 241-6, 2014 Nov.
Article en En | MEDLINE | ID: mdl-25306260
ABSTRACT

AIMS:

Low-density lipoprotein (LDL)-apheresis removes various molecules including LDL/oxidized LDL and inflammatory cytokines and recovers clinical laboratory parameters. It is not yet known whether these advantages of LDL-apheresis improve the prognosis of patients with diabetic nephropathy accompanied by nephrotic syndrome.

METHODS:

In this study, three groups of patients were retrospectively surveyed in a single center, and followed for approximately 3 years an LDL-apheresis cohort (LDL-a; N = 20); a control cohort meeting the selection criterion of severe proteinuria ≥ 3g/24h (control-All; N = 55); and a subgroup of control-All with more severe proteinuria ≥ 5 g/24h (control-mSP; N = 10), and evaluated the outcomes as survival and renal dysfunction and death/renal dysfunction free rate.

RESULTS:

Death/renal dysfunction free rate was significantly higher in LDL-a than control-All (χ(2) = 4.50; P = 0.03) and control-mSP (χ(2) = 27.68; P < 0.001).

CONCLUSION:

These results suggest the possibilities which LDL-apheresis is considered to contribute to survival extension and renal function maintenance of severe diabetic nephropathy patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 6_ODS3_enfermedades_notrasmisibles Problema de salud: 6_diabetes / 6_endocrine_disorders / 6_kidney_renal_pelvis_ureter_cancer Asunto principal: Eliminación de Componentes Sanguíneos / Nefropatías Diabéticas / Lipoproteínas LDL Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Diabetes Res Clin Pract Asunto de la revista: ENDOCRINOLOGIA Año: 2014 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 6_ODS3_enfermedades_notrasmisibles Problema de salud: 6_diabetes / 6_endocrine_disorders / 6_kidney_renal_pelvis_ureter_cancer Asunto principal: Eliminación de Componentes Sanguíneos / Nefropatías Diabéticas / Lipoproteínas LDL Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Diabetes Res Clin Pract Asunto de la revista: ENDOCRINOLOGIA Año: 2014 Tipo del documento: Article
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