Mitochondrial biogenesis in the acutely injured kidney.
Nephron Clin Pract
; 127(1-4): 42-5, 2014.
Article
en En
| MEDLINE
| ID: mdl-25343819
ABSTRACT
Mitochondrial dysfunction within the tubular epithelium has been implicated in the pathogenesis of acute kidney injury. Inflammatory, ischemic, or toxic insults dysregulate mitochondrial dynamics, resulting in mitochondrial swelling, fission, and apoptosis. The coordinated processes of generating healthy mitochondria and clearing damaged organelles may contribute to the preservation and restoration of mitochondrial homeostasis. Emerging literature suggests that a master regulator of mitochondrial biogenesis, peroxisome proliferator-activated receptor-γ-coactivator-1α (PGC-1α), is highly expressed in the tubular epithelium of the healthy kidney, and its induction during the post-injury period may contribute to functional recovery from acute kidney injury.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Lesión Renal Aguda
/
Recambio Mitocondrial
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nephron Clin Pract
Asunto de la revista:
NEFROLOGIA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Estados Unidos