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Analysis of the disposition of a novel p38 MAPK inhibitor, AKP-001, and its metabolites in rats with a simple physiologically based pharmacokinetic model.
Shirota, Kazuhiko; Kaneko, Makoto; Sasaki, Makoto; Minato, Kouichi; Fujikata, Akira; Ohta, Shuji; Hisaka, Akihiro; Suzuki, Hiroshi.
Afiliación
  • Shirota K; Pharmacokinetic Research Department, Developmental Research Center (K.S., M.K., M.S., K.M., and A.F.) and Synthetic Research Department, Medicinal Research Center (S.O.), ASKA Pharmaceutical Co. Ltd., Kanagawa, Japan; Pharmacology and Pharmacokinetics (A.H.) and Department of Pharmacy (H.S.), The Un
  • Kaneko M; Pharmacokinetic Research Department, Developmental Research Center (K.S., M.K., M.S., K.M., and A.F.) and Synthetic Research Department, Medicinal Research Center (S.O.), ASKA Pharmaceutical Co. Ltd., Kanagawa, Japan; Pharmacology and Pharmacokinetics (A.H.) and Department of Pharmacy (H.S.), The Un
  • Sasaki M; Pharmacokinetic Research Department, Developmental Research Center (K.S., M.K., M.S., K.M., and A.F.) and Synthetic Research Department, Medicinal Research Center (S.O.), ASKA Pharmaceutical Co. Ltd., Kanagawa, Japan; Pharmacology and Pharmacokinetics (A.H.) and Department of Pharmacy (H.S.), The Un
  • Minato K; Pharmacokinetic Research Department, Developmental Research Center (K.S., M.K., M.S., K.M., and A.F.) and Synthetic Research Department, Medicinal Research Center (S.O.), ASKA Pharmaceutical Co. Ltd., Kanagawa, Japan; Pharmacology and Pharmacokinetics (A.H.) and Department of Pharmacy (H.S.), The Un
  • Fujikata A; Pharmacokinetic Research Department, Developmental Research Center (K.S., M.K., M.S., K.M., and A.F.) and Synthetic Research Department, Medicinal Research Center (S.O.), ASKA Pharmaceutical Co. Ltd., Kanagawa, Japan; Pharmacology and Pharmacokinetics (A.H.) and Department of Pharmacy (H.S.), The Un
  • Ohta S; Pharmacokinetic Research Department, Developmental Research Center (K.S., M.K., M.S., K.M., and A.F.) and Synthetic Research Department, Medicinal Research Center (S.O.), ASKA Pharmaceutical Co. Ltd., Kanagawa, Japan; Pharmacology and Pharmacokinetics (A.H.) and Department of Pharmacy (H.S.), The Un
  • Hisaka A; Pharmacokinetic Research Department, Developmental Research Center (K.S., M.K., M.S., K.M., and A.F.) and Synthetic Research Department, Medicinal Research Center (S.O.), ASKA Pharmaceutical Co. Ltd., Kanagawa, Japan; Pharmacology and Pharmacokinetics (A.H.) and Department of Pharmacy (H.S.), The Un
  • Suzuki H; Pharmacokinetic Research Department, Developmental Research Center (K.S., M.K., M.S., K.M., and A.F.) and Synthetic Research Department, Medicinal Research Center (S.O.), ASKA Pharmaceutical Co. Ltd., Kanagawa, Japan; Pharmacology and Pharmacokinetics (A.H.) and Department of Pharmacy (H.S.), The Un
Drug Metab Dispos ; 43(2): 217-26, 2015 Feb.
Article en En | MEDLINE | ID: mdl-25422274
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirimidinas / Antiinflamatorios no Esteroideos / Proteínas Quinasas p38 Activadas por Mitógenos / Inhibidores de Proteínas Quinasas / Isoxazoles / Hígado / Modelos Biológicos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Drug Metab Dispos Asunto de la revista: FARMACOLOGIA Año: 2015 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirimidinas / Antiinflamatorios no Esteroideos / Proteínas Quinasas p38 Activadas por Mitógenos / Inhibidores de Proteínas Quinasas / Isoxazoles / Hígado / Modelos Biológicos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Drug Metab Dispos Asunto de la revista: FARMACOLOGIA Año: 2015 Tipo del documento: Article