Periadventitial adipose-derived stem cell treatment halts elastase-induced abdominal aortic aneurysm progression.
Regen Med
; 9(6): 733-41, 2014.
Article
en En
| MEDLINE
| ID: mdl-25431910
ABSTRACT
AIM:
Demonstrate that periadventitial delivery of adipose-derived mesenchymal stem cells (ADMSCs) slows aneurysm progression in an established murine elastase-perfusion model of abdominal aortic aneurysm (AAA). MATERIALS &METHODS:
AAAs were induced in C57BL/6 mice using porcine elastase. During elastase perfusion, a delivery device consisting of a subcutaneous port, tubing and porous scaffold was implanted. Five days after elastase perfusion, 100,000 ADMSCs were delivered through the port to the aorta. After sacrifice at day 14, analyzed metrics included aortic diameter and structure of aortic elastin.RESULTS:
ADMSC treated aneurysms had a smaller diameter and less fragmented elastin versus saline controls.CONCLUSION:
Periadventitial stem cell delivery prevented the expansion of an established aneurysm between days 5 and 14 after elastase perfusion.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Elastasa Pancreática
/
Tejido Adiposo
/
Aneurisma de la Aorta Abdominal
/
Células Madre Mesenquimatosas
/
Adventicia
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Regen Med
Año:
2014
Tipo del documento:
Article
País de afiliación:
Estados Unidos