Pre-clinical evaluation of AZD-2014, a novel mTORC1/2 dual inhibitor, against renal cell carcinoma.

Zheng, Bing; Mao, Jia-Hui; Qian, Lin; Zhu, Hua; Gu, Dong-hua; Pan, Xiao-dong; Yi, Fang; Ji, Dong-mei

Zheng, Bing; Mao, Jia-Hui; Qian, Lin; Zhu, Hua; Gu, Dong-hua; Pan, Xiao-dong; Yi, Fang; Ji, Dong-mei.

Afiliación

Zheng B; Department of Urology, The Second Affiliated Hospital of Nantong University, Nantong 226000, China. Electronic address: bingzhengnantong@163.com.
Mao JH; Department of pathophysiology, Nantong University School of Medicine, Nantong, China.
Qian L; Department of Urology, The Second Affiliated Hospital of Nantong University, Nantong 226000, China.
Zhu H; Department of Urology, The Second Affiliated Hospital of Nantong University, Nantong 226000, China.
Gu DH; Department of Urology, The Second Affiliated Hospital of Nantong University, Nantong 226000, China.
Pan XD; Department of Urology, The Second Affiliated Hospital of Nantong University, Nantong 226000, China.
Yi F; Department of Nephrology, Zhongshan Hospital, Shanghai Institute for Kidney and Dialysis, Fudan University, Shanghai, China. Electronic address: fang.yi@zs-hospital.sh.cn.
Ji DM; Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai 200032, China. Electronic address: jidongmei2000@126.com.

Cancer Lett ; 357(2): 468-75, 2015 Feb 28.

Article en En | MEDLINE | ID: mdl-25444920

Asunto(s)

Carcinoma de Células Renales/tratamiento farmacológico; Neoplasias Renales/tratamiento farmacológico; Morfolinas/farmacología; Complejos Multiproteicos/antagonistas & inhibidores; Serina-Treonina Quinasas TOR/antagonistas & inhibidores; Animales; Apoptosis/efectos de los fármacos; Autofagia/efectos de los fármacos; Autofagia/genética; Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/metabolismo; Benzamidas; Western Blotting; Carcinoma de Células Renales/metabolismo; Carcinoma de Células Renales/patología; Línea Celular Tumoral; Ciclina D1/metabolismo; Ensayos de Selección de Medicamentos Antitumorales/métodos; Femenino; Humanos; Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo; Neoplasias Renales/metabolismo; Neoplasias Renales/patología; Diana Mecanicista del Complejo 1 de la Rapamicina; Diana Mecanicista del Complejo 2 de la Rapamicina; Ratones Desnudos; Complejos Multiproteicos/metabolismo; Inhibidores de Proteínas Quinasas/farmacología; Proteínas Proto-Oncogénicas c-akt/metabolismo; Pirimidinas; Interferencia de ARN; Serina-Treonina Quinasas TOR/metabolismo; Ensayos Antitumor por Modelo de Xenoinjerto/métodos

Palabras clave

AZD-2014; Autophagy; Renal cell carcinoma; Sensitization and hypoxia-inducible factor; mTOR

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Morfolinas / Complejos Multiproteicos / Serina-Treonina Quinasas TOR / Neoplasias Renales Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Cancer Lett Año: 2015 Tipo del documento: Article

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