Synthesis and evaluation of glyco-coated liposomes as drug carriers for active targeting in drug delivery systems.

Ueki, Akiharu; Un, Keita; Mino, Yuka; Yoshida, Mitsuru; Kawakami, Shigeru; Ando, Hiromune; Ishida, Hideharu; Yamashita, Fumiyoshi; Hashida, Mitsuru; Kiso, Makoto

Ueki, Akiharu; Un, Keita; Mino, Yuka; Yoshida, Mitsuru; Kawakami, Shigeru; Ando, Hiromune; Ishida, Hideharu; Yamashita, Fumiyoshi; Hashida, Mitsuru; Kiso, Makoto.

Afiliación

Ueki A; Department of Applied Bioorganic Chemistry, Gifu University, 1-1 Yanagido, Gifu-shi, Gifu 501-1193, Japan; Institute for Integrated Cell-Material Science (WPI program), Kyoto University, Yoshida-ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan.
Un K; Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-shimoadachi-cho, Sakyo-ku, Kyoto 606-8302, Japan.
Mino Y; Department of Applied Bioorganic Chemistry, Gifu University, 1-1 Yanagido, Gifu-shi, Gifu 501-1193, Japan.
Yoshida M; Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-shimoadachi-cho, Sakyo-ku, Kyoto 606-8302, Japan.
Kawakami S; Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-shimoadachi-cho, Sakyo-ku, Kyoto 606-8302, Japan.
Ando H; Department of Applied Bioorganic Chemistry, Gifu University, 1-1 Yanagido, Gifu-shi, Gifu 501-1193, Japan; Institute for Integrated Cell-Material Science (WPI program), Kyoto University, Yoshida-ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan.
Ishida H; Department of Applied Bioorganic Chemistry, Gifu University, 1-1 Yanagido, Gifu-shi, Gifu 501-1193, Japan.
Yamashita F; Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-shimoadachi-cho, Sakyo-ku, Kyoto 606-8302, Japan.
Hashida M; Institute for Integrated Cell-Material Science (WPI program), Kyoto University, Yoshida-ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan; Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-shimoadachi-cho, Sakyo-ku, Kyoto 606-8302, Japan.
Kiso M; Department of Applied Bioorganic Chemistry, Gifu University, 1-1 Yanagido, Gifu-shi, Gifu 501-1193, Japan; Institute for Integrated Cell-Material Science (WPI program), Kyoto University, Yoshida-ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address: kiso@gifu-u.ac.jp.

Carbohydr Res ; 405: 78-86, 2015 Mar 20.

Article en En | MEDLINE | ID: mdl-25500195

ABSTRACT

ABSTRACT

Novel sugar-conjugated cholesterols, ß-Gal-, α-Man-, ß-Man-, α-Fuc-, and ß-Man-6P-S-ß-Ala-Chol, were synthesized and incorporated into liposomes. In vitro experiments using the glyco-coated liposomes showed that the glyco-coated liposomes are efficiently taken up by cells expressing carbohydrate-binding receptors selectively. Glyco-coated liposomes are promising candidates for drug delivery vehicles.

Asunto(s)

Carbohidratos/química; Colesterol/química; Liposomas/química; Liposomas/síntesis química; Animales; Transporte Biológico; Técnicas de Química Sintética; Células Hep G2; Humanos; Liposomas/metabolismo; Melanoma Experimental; Ratones

Palabras clave

Active targeting; Drug delivery system; Liposome; Sugar-binding receptor; Thioglycoside

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbohidratos / Colesterol / Liposomas Límite: Animals / Humans Idioma: En Revista: Carbohydr Res Año: 2015 Tipo del documento: Article País de afiliación: Japón

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