Expression of adhesion molecules and the proliferative activity of carcinosarcoma of the ovary.
Anticancer Res
; 34(12): 7351-6, 2014 Dec.
Article
en En
| MEDLINE
| ID: mdl-25503171
ABSTRACT
BACKGROUND:
To clarify the mechanism underlying the formation of a sarcomatous component of ovarian carcinosarcoma, we investigated the expression of adhesion molecules and the proliferative activity of carcinosarcomas. MATERIALS ANDMETHODS:
We immunohistochemically examined the expression of E-cadherin and ß-catenin, and the Ki-67 labeling index (Ki-67 LI) in six carcinosarcomas containing endometrioid carcinoma as a carcinomatous component.RESULTS:
The sarcomatous components of the carcinosarcomas did not express E-cadherin or ß-catenin. All carcinomatous components expressed these molecules but the expression was reduced compared to that in endometrioid ovarian carcinomas. In five of the six carcinosarcomas, the Ki-67 LI of the sarcomatous component was less than that of the carcinomatous component.CONCLUSION:
The present results suggest that a carcinomatous component transforms more easily than an ordinary endometrioid carcinoma from the viewpoint of the cell adhesion, and cells in a carcinomatous component continuously transform into sarcomatous cells during the growth of carcinosarcoma.Palabras clave
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Ováricas
/
Carcinosarcoma
/
Moléculas de Adhesión Celular
/
Carcinoma Endometrioide
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Anticancer Res
Año:
2014
Tipo del documento:
Article
País de afiliación:
Japón