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First-in-human trial of a novel suprachoroidal retinal prosthesis.
Ayton, Lauren N; Blamey, Peter J; Guymer, Robyn H; Luu, Chi D; Nayagam, David A X; Sinclair, Nicholas C; Shivdasani, Mohit N; Yeoh, Jonathan; McCombe, Mark F; Briggs, Robert J; Opie, Nicholas L; Villalobos, Joel; Dimitrov, Peter N; Varsamidis, Mary; Petoe, Matthew A; McCarthy, Chris D; Walker, Janine G; Barnes, Nick; Burkitt, Anthony N; Williams, Chris E; Shepherd, Robert K; Allen, Penelope J.
Afiliación
  • Ayton LN; Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
  • Blamey PJ; Bionics Institute, East Melbourne, Australia; Department of Medical Bionics, University of Melbourne, East Melbourne, Australia.
  • Guymer RH; Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
  • Luu CD; Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
  • Nayagam DA; Bionics Institute, East Melbourne, Australia; Department of Pathology, University of Melbourne, St Vincent's Hospital Melbourne, Fitzroy, Australia.
  • Sinclair NC; Bionics Institute, East Melbourne, Australia.
  • Shivdasani MN; Bionics Institute, East Melbourne, Australia; Department of Medical Bionics, University of Melbourne, East Melbourne, Australia.
  • Yeoh J; Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
  • McCombe MF; Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
  • Briggs RJ; Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
  • Opie NL; Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
  • Villalobos J; Bionics Institute, East Melbourne, Australia.
  • Dimitrov PN; Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
  • Varsamidis M; Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
  • Petoe MA; Bionics Institute, East Melbourne, Australia.
  • McCarthy CD; NICTA, Computer Vision Research Group, Canberra, Australia; National Institute for Mental Health Research, Australian National University, Canberra, Australia.
  • Walker JG; NICTA, Computer Vision Research Group, Canberra, Australia; National Institute for Mental Health Research, Australian National University, Canberra, Australia.
  • Barnes N; NICTA, Computer Vision Research Group, Canberra, Australia; National Institute for Mental Health Research, Australian National University, Canberra, Australia.
  • Burkitt AN; Bionics Institute, East Melbourne, Australia; Centre for Neural Engineering, University of Melbourne, National Information and Communications Technology Australia (NICTA), Ltd., Melbourne, Australia.
  • Williams CE; Bionics Institute, East Melbourne, Australia.
  • Shepherd RK; Bionics Institute, East Melbourne, Australia; Department of Medical Bionics, University of Melbourne, East Melbourne, Australia.
  • Allen PJ; Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
PLoS One ; 9(12): e115239, 2014.
Article en En | MEDLINE | ID: mdl-25521292
ABSTRACT
UNLABELLED Retinal visual prostheses ("bionic eyes") have the potential to restore vision to blind or profoundly vision-impaired patients. The medical bionic technology used to design, manufacture and implant such prostheses is still in its relative infancy, with various technologies and surgical approaches being evaluated. We hypothesised that a suprachoroidal implant location (between the sclera and choroid of the eye) would provide significant surgical and safety benefits for patients, allowing them to maintain preoperative residual vision as well as gaining prosthetic vision input from the device. This report details the first-in-human Phase 1 trial to investigate the use of retinal implants in the suprachoroidal space in three human subjects with end-stage retinitis pigmentosa. The success of the suprachoroidal surgical approach and its associated safety benefits, coupled with twelve-month post-operative efficacy data, holds promise for the field of vision restoration. TRIAL REGISTRATION Clinicaltrials.gov NCT01603576.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Procedimientos Quirúrgicos Oftalmológicos / Retinitis Pigmentosa / Prótesis Visuales Límite: Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2014 Tipo del documento: Article País de afiliación: Australia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Procedimientos Quirúrgicos Oftalmológicos / Retinitis Pigmentosa / Prótesis Visuales Límite: Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2014 Tipo del documento: Article País de afiliación: Australia