Poly(lactic acid) and poly(lactic-co-glycolic acid) particles as versatile carrier platforms for vaccine delivery.
Nanomedicine (Lond)
; 9(17): 2703-18, 2014 Dec.
Article
en En
| MEDLINE
| ID: mdl-25529572
ABSTRACT
The development of safe and effective vaccines for cancer and infectious diseases remains a major goal in public health. Over the last two decades, controlled release of vaccine antigens and immunostimulant molecules has been achieved using nanometer or micron-sized delivery vehicles synthesized using biodegradable polymers. In addition to achieving a depot effect, enhanced vaccine efficacy using such delivery vehicles has been attributed to efficient targeting of antigen presenting cells such as dendritic cells. Biodegradable and biocompatible poly(lactic acid) and poly(lactic-co-glycolic acid) polymers belong to one such family of polymers that have been a popular choice of material used in the design of these delivery vehicles. This review summarizes research findings from ourselves and others highlighting the promise of poly(lactic acid)- and poly(lactic-co-glycolic acid)-based vaccine carriers in enhancing immune responses.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácido Poliglicólico
/
Polímeros
/
Vacunas
/
Sistemas de Liberación de Medicamentos
/
Ácido Láctico
Límite:
Humans
Idioma:
En
Revista:
Nanomedicine (Lond)
Año:
2014
Tipo del documento:
Article
País de afiliación:
Reino Unido