[The role of cyclic nucleotides in reparative bone formation]. / Rol' tsiklicheskikh nukleotidov v reparativnom kosteobrazovanii.
Vopr Med Khim
; 35(4): 9-11, 1989.
Article
en Ru
| MEDLINE
| ID: mdl-2554593
ABSTRACT
Distinct alterations in content of cyclic nucleotides were observed during treatment of 133 patients with fractures of long tubular bones. The following effects were found after initial increase in cAMP content increase in tissue permeability, aseptic inflammation, inhibition of cell mitosis, acceleration of cell enzymes synthesis, of protein biosynthesis and of the rate of microcirculation in the traumatized region. Elevation of cGMP concentration led to initiation of bone marrow proliferation, to augmented formation of organic matrix and its mineralization. Monitoring of cyclic nucleotides concentration enabled to evaluate the reparative osteogenesis activity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
AMP Cíclico
/
GMP Cíclico
/
Fracturas Cerradas
Límite:
Humans
Idioma:
Ru
Revista:
Vopr Med Khim
Año:
1989
Tipo del documento:
Article