Improved mass detection in 3D automated breast ultrasound using region based features and multi-view information.

Breast cancer is one of the leading causes of cancer death for women. Early detection of breast cancer is crucial for reducing mortality rates and improving prognosis of patients. Recently, 3D automated breast ultrasound (ABUS) has gained increasing attentions for reducing subjectivity, operator-dependence, and providing 3D context of the whole breast. In this work, we propose a breast mass detection algorithm improving voxel-based detection results by incorporating 3D region-based features and multi-view information in 3D ABUS images. Based on the candidate mass regions produced by voxel-based method, our proposed approach further improves the detection results with three major steps: 1) 3D mass segmentation in geodesic active contours framework with edge points obtained from directional searching; 2) region-based single-view and multi-view feature extraction; 3) support vector machine (SVM) classification to discriminate candidate regions as breast masses or normal background tissues. 22 patients including 51 3D ABUS volumes with 44 breast masses were used for evaluation. The proposed approach reached sensitivities of 95%, 90%, and 70% with averaged 4.3, 3.8, and 1.6 false positives per volume, respectively. The results also indicate that the multi-view information plays an important role in false positive reduction in 3D breast mass detection.