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Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumor growth.
Ran, Leili; Sirota, Inna; Cao, Zhen; Murphy, Devan; Chen, Yuedan; Shukla, Shipra; Xie, Yuanyuan; Kaufmann, Michael C; Gao, Dong; Zhu, Sinan; Rossi, Ferdinando; Wongvipat, John; Taguchi, Takahiro; Tap, William D; Mellinghoff, Ingo K; Besmer, Peter; Antonescu, Cristina R; Chen, Yu; Chi, Ping.
Afiliación
  • Ran L; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Sirota I; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Cao Z; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Murphy D; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Chen Y; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Shukla S; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Xie Y; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Kaufmann MC; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Pharmacology, Weill Cornell Medical College, New York, New York.
  • Gao D; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Zhu S; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Rossi F; Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Wongvipat J; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Taguchi T; Division of Human Health and Medical Science, Graduate School of Kuroshio Science, Kochi University, Nankoku, Kochi, Japan.
  • Tap WD; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Medicine, Weill Cornell Medical College, New York, New York.
  • Mellinghoff IK; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Pharmacology, Weill Cornell Medical College, New York, New York. Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Besmer P; Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Antonescu CR; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Chen Y; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Medicine, Weill Cornell Medical College, New York, New York. Cell and Developmental Biology, Weill Co
  • Chi P; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Medicine, Weill Cornell Medical College, New York, New York. Cell and Developmental Biology, Weill Co
Cancer Discov ; 5(3): 304-15, 2015 Mar.
Article en En | MEDLINE | ID: mdl-25572173
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción / Transducción de Señal / Proteínas Proto-Oncogénicas c-kit / Proteínas Quinasas Activadas por Mitógenos / Tumores del Estroma Gastrointestinal / Inhibidores de Proteínas Quinasas / Proteínas de Unión al ADN / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Cancer Discov Año: 2015 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción / Transducción de Señal / Proteínas Proto-Oncogénicas c-kit / Proteínas Quinasas Activadas por Mitógenos / Tumores del Estroma Gastrointestinal / Inhibidores de Proteínas Quinasas / Proteínas de Unión al ADN / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Cancer Discov Año: 2015 Tipo del documento: Article