Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity.
Autophagy
; 11(1): 145-54, 2015.
Article
en En
| MEDLINE
| ID: mdl-25585051
Palabras clave
AGRP, agouti-related peptide; ATG12; ATG5; BAC, bacterial artificial chromosome; BMD, bone mineral density; BafA, bafilomycin A1; CLAMS, Comprehensive Lab Animal Monitoring System; DEXA, dual energy X-ray absorptiometry; HBSS, Hank's balanced salt solution; HFD, high-fat diet; LC3-II, phosphatidylethanolamine conjugated isoform of microtubule-associated protein 1 light chain 3; LEP, leptin; MAP1LC3, microtubule-associated protein 1 light chain 3; MEFs, mouse embryonic fibroblasts; NBR1, neighbor of BRCA1 gene 1; NPY, neuropeptide Y; PBS, phosphate-buffered saline; PE, phosphatidylethanolamine; POMC; POMC/ACTH, pro-opiomelanocortin-α (in mice), proopiomelanocortin (in humans); SQSTM1/p62, sequestosome 1; SV40Tag, simian virus 40 T antigen; UBL, ubiquitin-like molecule; autophagy; diet-induced obesity; hypothalamus; leptin; pSTAT3, phosphorylated form of signal transducer and activator of transcription 3 (acute-phase response factor)
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proopiomelanocortina
/
Proteínas
/
Dieta Alta en Grasa
/
Proteínas Asociadas a Microtúbulos
/
Neuronas
/
Obesidad
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Autophagy
Año:
2015
Tipo del documento:
Article
