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The potent BACE1 inhibitor LY2886721 elicits robust central Aß pharmacodynamic responses in mice, dogs, and humans.
May, Patrick C; Willis, Brian A; Lowe, Stephen L; Dean, Robert A; Monk, Scott A; Cocke, Patrick J; Audia, James E; Boggs, Leonard N; Borders, Anthony R; Brier, Richard A; Calligaro, David O; Day, Theresa A; Ereshefsky, Larry; Erickson, Jon A; Gevorkyan, Hykop; Gonzales, Celedon R; James, Douglas E; Jhee, Stanford S; Komjathy, Steven F; Li, Linglin; Lindstrom, Terry D; Mathes, Brian M; Martényi, Ferenc; Sheehan, Scott M; Stout, Stephanie L; Timm, David E; Vaught, Grant M; Watson, Brian M; Winneroski, Leonard L; Yang, Zhixiang; Mergott, Dustin J.
Afiliación
  • May PC; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
  • Willis BA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
  • Lowe SL; National University of Singapore Centre for Clinical Pharmacology, Singapore 117597, Singapore.
  • Dean RA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
  • Monk SA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
  • Cocke PJ; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
  • Audia JE; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
  • Boggs LN; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
  • Borders AR; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
  • Brier RA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
  • Calligaro DO; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
  • Day TA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
  • Ereshefsky L; PAREXEL International, Glendale, California 91206, and.
  • Erickson JA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
  • Gevorkyan H; California Clinical Trials Medical Group, Inc., Glendale, California 91206.
  • Gonzales CR; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
  • James DE; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
  • Jhee SS; PAREXEL International, Glendale, California 91206, and.
  • Komjathy SF; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
  • Li L; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
  • Lindstrom TD; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
  • Mathes BM; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
  • Martényi F; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
  • Sheehan SM; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
  • Stout SL; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
  • Timm DE; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
  • Vaught GM; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
  • Watson BM; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
  • Winneroski LL; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
  • Yang Z; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
  • Mergott DJ; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, mergott_dustin_james@lilly.com.
J Neurosci ; 35(3): 1199-210, 2015 Jan 21.
Article en En | MEDLINE | ID: mdl-25609634
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Picolínicos / Inhibidores de Proteasas / Péptidos beta-Amiloides / Ácido Aspártico Endopeptidasas / Secretasas de la Proteína Precursora del Amiloide / Enfermedad de Alzheimer / Compuestos Heterocíclicos con 2 Anillos Tipo de estudio: Clinical_trials Límite: Animals / Humans Idioma: En Revista: J Neurosci Año: 2015 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Picolínicos / Inhibidores de Proteasas / Péptidos beta-Amiloides / Ácido Aspártico Endopeptidasas / Secretasas de la Proteína Precursora del Amiloide / Enfermedad de Alzheimer / Compuestos Heterocíclicos con 2 Anillos Tipo de estudio: Clinical_trials Límite: Animals / Humans Idioma: En Revista: J Neurosci Año: 2015 Tipo del documento: Article