Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease.

Sang, Zhipei; Li, Yan; Qiang, Xiaoming; Xiao, Ganyuan; Liu, Qiang; Tan, Zhenghuai; Deng, Yong

Sang, Zhipei; Li, Yan; Qiang, Xiaoming; Xiao, Ganyuan; Liu, Qiang; Tan, Zhenghuai; Deng, Yong.

Afiliación

Sang Z; Department of Medicinal Chemistry, Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Li Y; Department of Medicinal Chemistry, Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Qiang X; Department of Medicinal Chemistry, Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Xiao G; Department of Medicinal Chemistry, Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Liu Q; Department of Medicinal Chemistry, Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Tan Z; Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041, China. Electronic address: tanzhh616@163.com.
Deng Y; Department of Medicinal Chemistry, Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China. Electronic address: dengyong@scu.edu.cn.

Bioorg Med Chem ; 23(4): 668-80, 2015 Feb 15.

Article en En | MEDLINE | ID: mdl-25614117

Asunto(s)

Enfermedad de Alzheimer/tratamiento farmacológico; Antioxidantes/uso terapéutico; Apigenina/uso terapéutico; Quelantes/uso terapéutico; Inhibidores de la Colinesterasa/uso terapéutico; Cognición/efectos de los fármacos; Glucuronatos/uso terapéutico; Fármacos Neuroprotectores/uso terapéutico; Acetilcolinesterasa/metabolismo; Enfermedad de Alzheimer/metabolismo; Animales; Antioxidantes/química; Antioxidantes/farmacocinética; Apigenina/química; Apigenina/farmacocinética; Barrera Hematoencefálica/metabolismo; Butirilcolinesterasa/metabolismo; Carbamatos/química; Carbamatos/farmacocinética; Carbamatos/uso terapéutico; Línea Celular; Quelantes/química; Quelantes/farmacocinética; Inhibidores de la Colinesterasa/química; Inhibidores de la Colinesterasa/farmacocinética; Glucuronatos/química; Glucuronatos/farmacocinética; Humanos; Ratones; Simulación del Acoplamiento Molecular; Fármacos Neuroprotectores/química; Fármacos Neuroprotectores/farmacocinética; Ratas

Palabras clave

Alzheimer's disease; Antioxidant activity; Cholinesterase inhibitors; Metal-chelating agents; Neuroprotective effects; Scutellarein carbamate derivatives

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quelantes / Inhibidores de la Colinesterasa / Cognición / Fármacos Neuroprotectores / Apigenina / Enfermedad de Alzheimer / Glucuronatos / Antioxidantes Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: China

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