[Determination of 2-hydroxyestrone /16α-hydroxyestrone ratio in urine of Mexican women as a risk indicator for breast cancer and its relationship with other risk factors]. / Determinación de la relación 2-hidroxiestrona/16α-hidroxiestrona en la orina de mujeres mexicanas como indicador de riesgo a cáncer de mama y su relación con otros factores de riesgo.

ABSTRACT

UNLABELLED The urinary ratio 2-hydroxyoestrone/16-hydroxyoestrone (URME), has been proposed in various populations on the world as a risk indicator for breast cancer (BC), however in the Mexican population has never been determined. OBJECTIVE: To determine URME Mexican women and establish its relationship with risk factors for BC. MATERIAL AND METHODS: Cross-sectional study of 142 premenopausal and 42 posmenopausal women. The URME was determined with the kit ESTRAMETTM and was related to risk factors for BC. Correlations and linear regressions were performed. RESULTS: The median URME was 0.90 (RIQ 0.64-1.18). The body mass index (BMI) and early menarche contribute 5.4% of their variability (F=5.17; p.

RESUMEN

La relacion 2-hidroxiestrona/16-hidroxiestrona urinaria (RMEO), se ha propuesto en diversas poblaciones del mundo como indicador de riesgo a cancer de mama (CM), sin embargo, en la poblacion mexicana, nunca se ha determinado. Objetivo: Determinar la RMEO en mujeres mexicanas y establecer su relacion con factores de riesgo para CM. Material y Métodos: Estudio transversal analitico de 142 mujeres premenopausicas y 42 posmenopausicas. Se determino la RMEO con el estuche ESTRAMETTM y se relaciono con factores de riesgo para CM. Se realizaron correlaciones y regresiones lineales. Resultados: La mediana de la RMEO fue 0.90 (RIC 0.64-1.18). El indice de masa corporal (IMC) y la menarca temprana contribuyeron en 5.4% de su variabilidad (F=5.17; p.