Innate immunity in solid organ transplantation: an update and therapeutic opportunities.
Expert Rev Clin Immunol
; 11(3): 377-89, 2015 Mar.
Article
en En
| MEDLINE
| ID: mdl-25644774
ABSTRACT
Innate immunity is increasingly recognized as a major player in transplantation. In addition to its role in inflammation in the early post-transplant period, innate immunity shapes the differentiation of cells of adaptive immunity, with a capacity to promote either rejection or tolerance. Emerging data indicate that innate allorecognition, a characteristic previously limited to lymphocytes, is involved in allograft rejection. This review briefly summarizes the physiology of each component of the innate immune system in the context of transplantation and presents the current or promising therapeutic applications, such as cellular, anticomplement and anticytokine therapies.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trasplante de Órganos
/
Rechazo de Injerto
/
Inmunosupresores
/
Macrófagos
/
Anticuerpos Monoclonales
Tipo de estudio:
Etiology_studies
/
Observational_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Expert Rev Clin Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Canadá