A multicenter outcomes analysis of children with severe rhino/enteroviral respiratory infection.
Pediatr Crit Care Med
; 16(2): 119-23, 2015 Feb.
Article
en En
| MEDLINE
| ID: mdl-25647121
ABSTRACT
OBJECTIVES:
To investigate the impact of human rhino/enteroviruses on morbidity and mortality outcomes in children with severe viral respiratory infection.DESIGN:
Retrospective cohort study.SETTING:
The ICU, either PICU or cardiac ICU, at three urban academic tertiary-care children's hospitals. PATIENTS All patients with laboratory-confirmed human rhino/enteroviruses infection between January 2010 and June 2011.INTERVENTIONS:
We captured demographic and clinical data and analyzed associated morbidity and mortality outcomes. MEASUREMENTS AND MAINRESULTS:
There were 519 patients included in our analysis. The median patient age was 2.7 years. The median hospital and ICU lengths of stay were 4 days and 2 days, respectively. Thirty-four percent of patients had a history of asthma, and 25% of patients had a chronic medical condition other than asthma. Thirty-two percent of patients required mechanical ventilation. Eleven patients (2.1%) did not survive to hospital discharge. The rate of viral coinfection was 12.5% and was not associated with mortality. Predisposing factors associated with increased mortality included immunocompromised state (p < 0.001), ICU admission severity of illness score (p < 0.001), and bacterial coinfection (p = 0.003).CONCLUSIONS:
There is substantial morbidity associated with severe respiratory infection due to human rhino/enteroviruses in children. Mortality was less severe than reported in other respiratory viruses such as influenza and respiratory syncytial virus. The burden of illness from human rhino/enteroviruses in the ICU in terms of resource utilization may be considerable.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones del Sistema Respiratorio
/
Rhinovirus
/
Enterovirus
/
Infecciones por Picornaviridae
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Newborn
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Pediatr Crit Care Med
Asunto de la revista:
PEDIATRIA
/
TERAPIA INTENSIVA
Año:
2015
Tipo del documento:
Article