Prostaglandin agonist effect on matrix metalloproteinase aqueous levels in glaucoma patients.
Can J Ophthalmol
; 50(1): 6-10, 2015 Feb.
Article
en En
| MEDLINE
| ID: mdl-25677276
ABSTRACT
OBJECTIVE:
To determine whether the aqueous levels of matrix metalloproteinases (MMPs) differ between patients with glaucoma treated with topical prostaglandin analogues and normal, nonglaucomatous control patients. Also, to note any difference in MMP levels between latanoprost, travoprost, and bimatoprost that might suggest a difference in efficacy or mechanism of action between these drugs.DESIGN:
Prospective, observational study.PARTICIPANTS:
Patients who were scheduled to undergo routine intraocular surgery (phacoemulsification or combined phacotrabeculectomy) as part of their standard clinical care were included. Eighteen eyes of 18 patients with glaucoma using any 1 prostaglandin analogue (latanoprost, travoprost, or bimatoprost) were compared with 8 normal control patients.METHODS:
This was a multicentre study. Aqueous humour (0.2 mL) was aspirated at the beginning of the intraocular surgery through a clear corneal paracentesis. MMP-2 and -9 were quantified in the aqueous of all participants using enzyme-linked immunosorbent assay.RESULTS:
There was no significant difference in the levels of either MMP-2 (p = 0.216) or MMP-9 (p = 0.552) between the control patients and the patients with glaucoma on prostaglandins. There was no difference in the levels of MMP-2 or -9 between the latanoprost, travoprost, or bimatoprost groups.CONCLUSIONS:
The levels of MMP-2 and -9 in aqueous of glaucomatous eyes on topical prostaglandin analogues were the same as those of normal age-matched control patients. This could reflect either a return to normal levels with efficacious treatment or a lack of difference between disease and nondisease states.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Humor Acuoso
/
Prostaglandinas F Sintéticas
/
Glaucoma
/
Metaloproteinasa 2 de la Matriz
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Metaloproteinasa 9 de la Matriz
/
Antihipertensivos
Tipo de estudio:
Clinical_trials
/
Observational_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Can J Ophthalmol
Año:
2015
Tipo del documento:
Article