Cytotoxic indole alkaloids from Tabernaemontana officinalis.
Phytochemistry
; 120: 46-52, 2015 Dec.
Article
en En
| MEDLINE
| ID: mdl-25687604
ABSTRACT
Continued interest in cytotoxic alkaloids resulted in the isolation of 37 alkaloids including 29 known monoterpenoid indole alkaloids from the aerial parts of Tabernaemontana officinalis. Of the remaining 8 alkaloids, six were bisindole alkaloids named taberdivarines A-F (1-6) and the two were monomers named taberdivarines G and H (7-8). Alkaloids 1 and 2 are voaphylline-vobasinyl type bisindole alkaloids, a structural type previously unknown, while 3-6 exhibited cytotoxicity against three human cancer cell lines HeLa, MCF-7, and SW480 with IC50 values ranging from 1.42 to 11.35 µM.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tabernaemontana
/
Alcaloides de Triptamina Secologanina
/
Antineoplásicos Fitogénicos
Límite:
Humans
Idioma:
En
Revista:
Phytochemistry
Año:
2015
Tipo del documento:
Article