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Low-frequency magnetic fields do not aggravate disease in mouse models of Alzheimer's disease and amyotrophic lateral sclerosis.
Liebl, Martina P; Windschmitt, Johannes; Besemer, Anna S; Schäfer, Anne-Kathrin; Reber, Helmut; Behl, Christian; Clement, Albrecht M.
Afiliación
  • Liebl MP; Institute for Pathobiochemistry, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
  • Windschmitt J; Institute for Pathobiochemistry, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
  • Besemer AS; Institute for Pathobiochemistry, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
  • Schäfer AK; Institute for Pathobiochemistry, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
  • Reber H; Department of Nuclear Medicine, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
  • Behl C; Institute for Pathobiochemistry, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
  • Clement AM; Institute for Pathobiochemistry, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Sci Rep ; 5: 8585, 2015 Feb 26.
Article en En | MEDLINE | ID: mdl-25717019
Low-frequency magnetic fields (LF-MF) generated by power lines represent a potential environmental health risk and are classified as possibly carcinogenic by the World Health Organization. Epidemiological studies indicate that LF-MF might propagate neurodegenerative diseases like Alzheimer's disease (AD) or amyotrophic lateral sclerosis (ALS). We conducted a comprehensive analysis to determine whether long-term exposure to LF-MF (50 Hz, 1 mT) interferes with disease development in established mouse models for AD and ALS, namely APP23 mice and mice expressing mutant Cu/Zn-superoxide dismutase (SOD1), respectively. Exposure for 16 months did not aggravate learning deficit of APP23 mice. Likewise, disease onset and survival of SOD1(G85R) or SOD1(G93A) mice were not altered upon LF-MF exposure for ten or eight months, respectively. These results and an extended biochemical analysis of protein aggregation, glial activation and levels of toxic protein species suggests that LF-MF do not affect cellular processes involved in the pathogenesis of AD or ALS.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 Problema de salud: 2_cobertura_universal Asunto principal: Enfermedad de Alzheimer / Campos Magnéticos / Esclerosis Amiotrófica Lateral Límite: Animals Idioma: En Revista: Sci Rep Año: 2015 Tipo del documento: Article País de afiliación: Alemania

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 Problema de salud: 2_cobertura_universal Asunto principal: Enfermedad de Alzheimer / Campos Magnéticos / Esclerosis Amiotrófica Lateral Límite: Animals Idioma: En Revista: Sci Rep Año: 2015 Tipo del documento: Article País de afiliación: Alemania
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