Hybridization-induced Ag(I) dissociation from an immobilization-free and label-free hairpin DNA: toward a novel electronic monitoring platform.

ABSTRACT

A novel silver ion (Ag(+))-assisted hairpin DNA through C-Ag(+)-C coordination chemistry was designed for immobilization-free and label-free electrochemical monitoring of human immunodeficiency virus (HIV) DNA on a negatively charged indium-tin oxide electrode, based on hybridization-induced dissociation of silver ions from the hairpin DNA.