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Discovery of a Cyclic Boronic Acid ß-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases.
Hecker, Scott J; Reddy, K Raja; Totrov, Maxim; Hirst, Gavin C; Lomovskaya, Olga; Griffith, David C; King, Paula; Tsivkovski, Ruslan; Sun, Dongxu; Sabet, Mojgan; Tarazi, Ziad; Clifton, Matthew C; Atkins, Kateri; Raymond, Amy; Potts, Kristy T; Abendroth, Jan; Boyer, Serge H; Loutit, Jeffrey S; Morgan, Elizabeth E; Durso, Stephanie; Dudley, Michael N.
Afiliación
  • Hecker SJ; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States.
  • Reddy KR; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States.
  • Totrov M; ‡Molsoft L.L.C., 11199 Sorrento Valley Road, San Diego, California 92121, United States.
  • Hirst GC; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States.
  • Lomovskaya O; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States.
  • Griffith DC; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States.
  • King P; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States.
  • Tsivkovski R; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States.
  • Sun D; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States.
  • Sabet M; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States.
  • Tarazi Z; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States.
  • Clifton MC; §Beryllium, 3 Preston Court, Bedford, Massachusetts 01730, United States.
  • Atkins K; §Beryllium, 3 Preston Court, Bedford, Massachusetts 01730, United States.
  • Raymond A; §Beryllium, 3 Preston Court, Bedford, Massachusetts 01730, United States.
  • Potts KT; §Beryllium, 3 Preston Court, Bedford, Massachusetts 01730, United States.
  • Abendroth J; §Beryllium, 3 Preston Court, Bedford, Massachusetts 01730, United States.
  • Boyer SH; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States.
  • Loutit JS; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States.
  • Morgan EE; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States.
  • Durso S; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States.
  • Dudley MN; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States.
J Med Chem ; 58(9): 3682-92, 2015 May 14.
Article en En | MEDLINE | ID: mdl-25782055
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Ácidos Borónicos / Inhibidores de beta-Lactamasas / Compuestos Heterocíclicos con 1 Anillo / Antibacterianos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Ácidos Borónicos / Inhibidores de beta-Lactamasas / Compuestos Heterocíclicos con 1 Anillo / Antibacterianos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos