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Simultaneous evaluation of vascular morphology, blood volume and transvascular permeability using SPION-based, dual-contrast MRI: imaging optimization and feasibility test.
Kwon, Heon-Ju; Shim, Woo Hyun; Cho, Gyunggoo; Cho, Hyung Joon; Jung, Hoe Su; Lee, Chang Kyung; Lee, Yong Seok; Baek, Jin Hee; Kim, Eun Ju; Suh, Ji-Yeon; Sung, Yu Sub; Woo, Dong-Cheol; Kim, Young Ro; Kim, Jeong Kon.
Afiliación
  • Kwon HJ; Department of Radiology, Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Asan Institute for Life Sciences, Seoul, South Korea.
  • Shim WH; Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
  • Cho G; Department of Radiology, Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Asan Institute for Life Sciences, Seoul, South Korea.
  • Cho HJ; Division of Magnetic Resonance, Korea Basic Science Institute, Cheongwon, Chungbuk, South Korea.
  • Jung HS; Ulsan National Institute of Science and Technology, Ulsan, South Korea.
  • Lee CK; Ulsan National Institute of Science and Technology, Ulsan, South Korea.
  • Lee YS; Department of Radiology, Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Asan Institute for Life Sciences, Seoul, South Korea.
  • Baek JH; Division of Magnetic Resonance, Korea Basic Science Institute, Cheongwon, Chungbuk, South Korea.
  • Kim EJ; Department of Radiology, Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Asan Institute for Life Sciences, Seoul, South Korea.
  • Suh JY; Division of Magnetic Resonance, Korea Basic Science Institute, Cheongwon, Chungbuk, South Korea.
  • Sung YS; Department of Radiology, Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Asan Institute for Life Sciences, Seoul, South Korea.
  • Woo DC; Division of Magnetic Resonance, Korea Basic Science Institute, Cheongwon, Chungbuk, South Korea.
  • Kim YR; Philips Healthcare, Seoul, South Korea.
  • Kim JK; Division of Magnetic Resonance, Korea Basic Science Institute, Cheongwon, Chungbuk, South Korea.
NMR Biomed ; 28(6): 624-32, 2015 Jun.
Article en En | MEDLINE | ID: mdl-25865029
Exploiting ultrashort-T(E) (UTE) MRI, T1-weighted positive contrast can be obtained from superparamagnetic iron oxide nanoparticles (SPIONs), which are widely used as a robust T2-weighted, negative contrast agent on conventional MR images. Our study was designed (a) to optimize the dual-contrast MRI method using SPIONs and (b) to validate the feasibility of simultaneously evaluating the vascular morphology, blood volume and transvascular permeability using the dual-contrast effect of SPIONs. All studies were conducted using 3 T MRI. According to numerical simulation, 0.15 mM was the optimal blood SPION concentration for visualizing the positive contrast effect using UTE MRI (T(E) = 0.09 ms), and a flip angle of 40° could provide sufficient SPION-induced enhancement and acceptable measurement noise for UTE MR angiography. A pharmacokinetic study showed that this concentration can be steadily maintained from 30 to 360 min after the injection of 29 mg/kg of SPIONs. An in vivo study using these settings displayed image quality and CNR of SPION-enhanced UTE MR angiography (image quality score 3.5; CNR 146) comparable to those of the conventional, Gd-enhanced method (image quality score 3.8; CNR 148) (p > 0.05). Using dual-contrast MR images obtained from SPION-enhanced UTE and conventional spin- and gradient-echo methods, the transvascular permeability (water exchange index 1.76-1.77), cerebral blood volume (2.58-2.60%) and vessel caliber index (3.06-3.10) could be consistently quantified (coefficient of variation less than 9.6%; Bland-Altman 95% limits of agreement 0.886-1.111) and were similar to the literature values. Therefore, using the optimized setting of combined SPION-based MRI techniques, the vascular morphology, blood volume and transvascular permeability can be comprehensively evaluated during a single session of MR examination.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Volumen Sanguíneo / Permeabilidad Capilar / Arterias Cerebrales / Dextranos / Angiografía por Resonancia Magnética Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals Idioma: En Revista: NMR Biomed Asunto de la revista: DIAGNOSTICO POR IMAGEM / MEDICINA NUCLEAR Año: 2015 Tipo del documento: Article País de afiliación: Corea del Sur

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Volumen Sanguíneo / Permeabilidad Capilar / Arterias Cerebrales / Dextranos / Angiografía por Resonancia Magnética Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals Idioma: En Revista: NMR Biomed Asunto de la revista: DIAGNOSTICO POR IMAGEM / MEDICINA NUCLEAR Año: 2015 Tipo del documento: Article País de afiliación: Corea del Sur
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